2026 08 14: Last day for Postdoc Marie Gasser – (2y10m!)
2026 08 14: Last day for Postdoc Inès Cherkaoui – (2y9m!)
2026 08 12: 5@7 – Good bye Inès and Marie, thank you for everything !
2026 07 27: First day for Postdoc Keenan Flynn – Welcome aboard
2026 07 22 : Last day for summer trainee Vanessa Blaik (3 months)
2026 06 30: BBQ hosted by Guy – Let’s enjoy the summer
2026 06 30: Last day Postdoc Rana Melhem (4y10m!)
2026 06 25 : 5@7 Good bye Rana, thank you for everything !
2026 06 23 : A new article was published
Huang YC, Slak Rupnik M, Rutter GA. Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells. Commun Biol. 2026 Jun 23
PMID: 42337344
2026 06 22 : A new article was published
Trimigliozzi KA, Wiedemann SJ, Ostinelli G, Rachid L, Méreau H, Böni-Schnetzler M, Rutter GA, Meier DT, Donath MY. Pancreatic α-cells integrate immune and neuronal stimuli for insulin secretion. Cell Rep. 2026 Jul 28;45(7):117586.
PMID: 42329762
2026 06 16: Conference – Guy Rutter participated to Islet Study group (ISG) Annual Meeting, Barcelona, Spain
2026 06 16: 5@7 – Happy Birthday Luis !
2026 06 09 : A new article was published
Ward C, Banks-Tibbs T, Thorpe H, Giles AM, Mabry SJ, Liu JJ, Chang HC, Yang J, Carney AF, Shaikh HM, Woolley LM, Joseph PN, Kozel J, Rocha EM, Rutter GA, Tseng GC, Liu S, Pless LL, Freyberg Z. AI-guided analysis of human pancreatic islet sociology reveals distinct cell compositional changes in type 1 diabetes. bioRxiv [Preprint]. 2026 Jun 9:2026.06.05.730081.
PMID: 42327161
2026 05 15 : Last day for summer trainee Sofia Petersen (1 month)
2026 05 04 : First day for trainee Vanessa Blaik – Welcome aboard
2026 04 28: Conference – Guy Rutter participated to SPOD, Simpósio do Pâncreas, Obesidade e Diabetes, Florianópolis, Brasil
2026 04 21 : Last day Postdoc Shadai Salazar (3y4m!)
2026 04 20 : A new article was published
Gasser M, Cherkaoui I, Ostinelli G, Ferron M, Du Q, Egli D, Rutter GA. A loss of function variant in SLC30A8/ZnT8 drives proteomic changes associated with lowered apoptosis in human stem cell-derived islets. medRxiv [Preprint]. 2026 Apr 20
PMID: 42078397
2026 04 15 : A new article was published
Delgadillo-Silva LF, Ostinelli G, Provencher-Girard A, Salazar S, Melhem R, Rutter GA. Pancreatic islet cell calcium ion imaging at single-cell resolution: functional identification of first-responder, highly connected (“hub”), and leader beta-cells. Front Endocrinol (Lausanne). 2026 Apr 15;17:1802510. doi: 10.3389/fendo.2026.1802510. Erratum in: Front Endocrinol (Lausanne). 2026 May 13;17:1872081.
PMID: 42064760
2026 04 14 : First day for trainee Sofia Petersen – Welcome aboard
2026 04 13 : 5@7 Good bye Shadai, thank you for everything !
2026 03 31: Conference – Guy Rutter participated to Congrès annuel de la Société francophone du diabète (SFD), Lyon, France
2026 03 16: Conference – Guy Rutter participated to Keystone Symposia – Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery, Breckenridge, CO, USA
2026 03 10 : A new article was published
Tan WX, Amirruddin NS, Lim EXH, Hu M, Muralidharan S, Benke PI, Torta F, Hoon S, Soetedjo AAP, Lau HH, Ng NHJ, Rutter GA, Teo AKK. STARD10 regulates human pancreatic β cell differentiation and triglyceride metabolism. Stem Cell Reports. 2026 Mar 10;21(3):102815.
PMID: 41687621
2026 02 06 : A new article was published
El Eid L, Manchanda Y, Austin G, Deane-Alder K, Rujan RM, Mariam Z, Oqua AI, Belousoff MJ, de la Serna JB, Sloop KW, Rutter GA, Montoya A, Withers DJ, Millership SJ, Bouzakri K, Jones B, Reynolds CA, Sexton PM, Wootten D, Deganutti G, Tomas A. In vivo functional profiling and structural characterization of the human GLP1R A316T variant. Sci Adv. 2026 Feb 6;12(6):eadw0899.
PMID: 41637494
2026 02 05: Conference – Guy Rutter participated to Dutch Endocrine Meeting 2026, Veldhoven, Netherland
2026 02 04 : A new article was published
Sarwat S, Alen R, Wu Z, Zhang C, Paszek M, Yang M, Ostinelli G, Mihalovits A, Baker B, Wai T, Rutter GA, Rodriguez TA, Martinez-Sanchez A. MTFP1 preserves β-cell cristae structure and bioenergetics to ensure insulin release and glucose homeostasis. bioRxiv [Preprint]. 2026 Feb 3:2026.01.12.697845.
PMID: 41648185
2026 01 01 : A new article was published
Salazar S, Delgadillo-Silva LF, Carapeto P, Kenfaoui MM, Dakessian K, Melhem R, Provencher-Girard A, Ostinelli G, Turgeon J, Kaci I, Migneault F, Huising MO, Hébert MJ, Chaker-Margot M, Rutter GA. Additive Effects of Dorzagliatin and Glucagon-Like Peptide 1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice. Diabetes. 2026 Jan 1;75(1):99-114.
PMID: 41196662
2025 12 10 : Rutter Lab had Holiday celebration at restaurant La Raclette, Montreal, Canada
2025 12 10 : A new article was published
Delgadillo-Silva LF, Dakessian K, Provencher-Girard A, Louch WE, Rutter GA. ER calcium stores contribute to glucose-induced Ca2+ waves and intercellular connectivity in mouse pancreatic islets. Cell Calcium. 2026 Jan;133:103093.
PMID: 41418583
2025 11 29 : Guy Rutter and Shadai Salazar participated to the CIHR mid-term meeting, Toronto, Canada
2025 11 13 : A new article was published
Tang, A., Lepage, M., Rutter, GA, Carpentier, A.C. Editorial: In vivo magnetic resonance imaging of metabolic disorders. Fr. Endocr 16:1713999 (2025)
PMID: 41323968
2025 11 10 : A new article was published
He S, Meister D, Khan S, Mohammadzadeh A, Delgadillo Silva L, Rutter GA, Trant JF, Lim GE. A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins. Cell Death Dis. 2025 Nov 10;16(1):825.
PMID: 41213973
2025 09 26 : A new article was published
Ho QWC, Miller JA, Gunaseelan D, Chelliah R, Babu HJ, Chew XY, Devaraj S, Tay VS, Kong D, Wang X, Tan DY, Rutter GA, Lee B, Teo AKK, Ali Y. I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression. Diabetologia. 2025 Dec;68(12):2767-2780.
PMID: 41003698
2025 09 15-19 Conference: Guy Rutter, Giada Ostinelli, Marie Gasser and Inès Cherkaoui participated to the 61st annual meeting of EASD, Vienne, Austria
2025 09 12 Conference: Guy Rutter was an Invited Speaker to TDNF mini-symposium The ever-expending RNA world – A diabetes research journey, Lausane, Switzerland
2025 08 28: A new article was published
Huang YC, Slak Rupnik M, Rutter GA. Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells. bioRxiv [Preprint]. 2025 Aug 28:2025.08.23.671946. doi: 10.1101/2025.08.23.671946. Update in: Commun Biol. 2026 Jun 23.
PMID: 40909609
2025 08 20: A new article was published
Manchanda Y, Jones B, Carrat G, Ramchunder Z, Marchetti P, Leclerc I, Thennati R, Burade V, Natarajan M, Shahi P, Tomas A, Rutter GA. Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel GLP-1R/GIPR dual agonist, HISHS-2001. Diabetes Obes Metab. 2025 Oct;27(10):5938-5949.
PMID: 40831316
2025 08 26-28 Conference: Guy Rutter was an Invited Speaker to Trans-scale imaging and integrated islet biology symposium, Beijing, China
2025 07 21: A new article was published
Li, J., Deng, Y., Gasser, M., Zhu, J., Walker, E.M., Sidarala, V., Reck, E.C., Hubers, D.L., Pasmooij., M.B., Shin, C-S., bandesh, K., Motakis, E., Nargund, S., Kursawe, R., Basrur, V., Nesvizhskii, A.I., Stitzel, M.L., Chan, D.C., Rutter, G.A. and Soleimanpour, S.A. LonP1 regulation of mitochondirla protein folding provides insights into beta cell failure in type 2 diabetes. Nat. Metab 7(8):1570-1592 (2025)
PMID: 40691304
2025 07 09: Guy Rutter was present for AMS New Fellow Admission Day, London, UK
2025 06 20-23 Conference: Participation to the 2025 American Diabetes Association Conference, Chicago, USA
2025 06 11-13 Conference: Participation to the 2025 European Islet Study Group Meeting in Malmö, Sweden
2025 05 22 Guy Rutter is elected as a Fellows at the Academy of Medical Science. Link to the Press Release. A celebration in the Cardiometabolic Axis in CRCHUM took place in the afternoon.
2025 04 05-06 Conference: Participation to Boston Ithaca Islet Club (BIIC) 2025, taking place in CRCHUM this year.
2025 02 21 The whole group invited to share a ski trip to Mont Orford.
2025 01 29 Happy Hours for Lab Rutter in a Microbrewery in Montreal’s “Quartier Latin”
2025 01 14 Guy Rutter participated to HIRN 2025, Washington DC, USA
2025 01 09 A new article was published
Dolgin V, Chabosseau P, Bistritzer J, Noyman I, Staretz-Chacham O, Wormser O, Hadar N, Eskin-Schwartz M, Kanengisser-Pines B, Narkis G, Abramsky R, Shany E, Rutter GA, Marks K, Birk OS. Severe neonatal hypotonia due to SLC30A5 variant affecting function of ZnT5 zinc transporter. JIMD Rep. 2025 Jan 9
PMID: 39790720
2025 01 06 Ayush Mehra joined the team as a Ph.D. student. Welcome in !
2024 12 11 A new article was published
Cherkaoui I, Du Q, Egli DM, Dion C, Leitch HG, Sachedina D, Misra S, Rutter GA. Investigating the pathogenicity of the recessive HNF1A p.A251T variant in monogenic diabetes using iPSC-derived beta-like cells. medRxiv [Preprint]. 2024 Dec 11
PMID: 39711726
2024 12 09 A new article was published
Lopez-Noriega L, Callingham R, Martinez-Sánchez A, Nawaz S, Pizza G, Haberman N, Cvetesic N, Nguyen-Tu MS, Lenhard B, Marchetti P, Piemonti L, de Koning E, Shapiro AMJ, Johnson PR, Leclerc I, Hastoy B, Gauthier BR, Pullen TJ, Rutter GA. Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell function. iScience. 2024 Dec 9
PMID: 39811653
2024 12 05 Funding Announcement Breakthrough T1D Grant
Project Title: A combined chemical synthetic / intravital imaging approach to explore the survival and function of human pluripotent derived islets after transplantation in mice.
Funding to be activated 2025 01 05.
2024 11 22 Rutter Lab participated to Diabetes Canada and CIRTN-R2FIC meetings 2024, in Halifax, Canada. Guy, Luis, Shadai, Priscila and Ya-Chi participated.
2024 11 18 A new article was published
Li S, Arora S, Attaoua R, et al. Leveraging hierarchical structures for genetic block interaction studies using the hierarchical transformer. Preprint. medRxiv. 2024;2024.11.18.24
317486. Published 2024 Nov 18.
PMID: 39606365
2024 11 11 A new article was published
Salazar S, Delgadillo-Silva LF, Carapeto P, Dakessian K, Melhem R, Provencher-Girard A, Ostinelli G, Turgeon J, Kaci I, Migneault F, Huising MO, Hébert MJ, Rutter GA. Sex-dependent additive effects of dorzagliatin and incretin on insulin secretion in a novel mouse model of GCK-MODY. bioRxiv [Preprint]. 2024 Nov 11
PMID: 39605321
2024 11 10 A new article was published
El Eid L, Deane-Alder K, Rujan RM, Mariam Z, Oqua AI, Manchanda Y, Belousoff MJ, Bernardino de la Serna J, Sloop KW, Rutter GA, Montoya A, Withers DJ, Millership SJ, Bouzakri K, Jones B, Reynolds CA, Sexton PM, Wootten D, Deganutti G, Tomas A. In vivo functional profiling and structural characterisation of the human Glp1r A316T variant. bioRxiv [Preprint]. 2024 Nov 10
PMID: 39484598
2024 11 06 An erratum was published
Rutter GA, Gresch A, Delgadillo Silva L, Benninger RKP. Exploring pancreatic beta-cell subgroups and their connectivity. Nat Metab. 2024 Nov;6(11):2039-2053.
PMID: 39117960
2024 10 18 Rutter Lab has a meeting in University of Toronto with “Breakthrough Type 1 Diabetes” collaborators around the T1D project. Guy, Shadai, Priscila and Giada participated.
2024 09 26 Happy Hours for Lab Rutter in an Irish Pub on Crescent Street
2024 09 13 Rutter Lab participed to EASD 2024 Meeting in Madrid, Spain. Guy, Marie and Inès participated.
2024 09 01 – Website inception
