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Publications

2026

Original Articles

  1. Salazar S., Delgadillo-Silva L., Carapeto P., Kenfaoui M.M., Dakessian K., Melhem R., Provencher-Girard A., Ostinelli G., Turgeon J., Kaci I., Migneault F., Huising M.O., Hébert M.J., Chaker-Margot M., Rutter G.A. Additive Effects of Dorzagliatin and Glucagon-Like Peptide 1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice. Diabetes 1;75(1):99-114 (2026)
  2. Delgadillo-Silva, L., Dakessian, K., Provencher-Girard, A., Louch, W.E., Rutter, G.A. ER Calcium stores contribute to glucose-induced Ca2+ waves and intercellular connectivity in mouse pancreatic islets. Cell Calcium 10;133:103093. doi: 10.1016/j.ceca.2025.103093 (2026)
  3. Tan, WX., Amirruddin, N.S., Euodia, X.H.L., Hu, M., Muralidharan, S., Banke, P., Torta, F., Hoon, S., Soetedjo, A.A.P., Lau, H.H.H., Ng, N.H.J., Rutter, G.A.* Teo, A.K.K. Type 2 Diabetes-associated STARD10 regulates the formation of β cells and their cellular bioenergetics Stem Cell Rep, 10;21(3):102815. doi: 10.1016/j.stemcr.2026.102815 (2026)
  4. El Eid, L., Deane-Alder, K., Rujan, R-M., Mariam, Z., Oqua, A.I., Manchanda, Y., Belousoff, M.J., Bernardino de la Serna, J., Sloop, K.S., Rutter, G.A., Montoya, A., Withers, D.J., Millership, S.J., Houzaraki, K., Jones, B., Reynolds, C.A., Sexton, P.M., Wootten, D., Deganutti, G., Tomas, A. In vivo functional profiling and structural characterisation of the human Glp1r A316T variant Sci Advances 12(6):eadw0899. doi: 10.1126/sciadv.adw0899 (2026)
  5. Trimigliozzi, K.A., Wiedemann, S.J., Ostinelli, G., Rachid, L., Méerau, H., Böni-Schnetzler, M., Rutter, G.A., Meier, D.T., Donath, M.Y. Pancreatic Alpha-cells integrate neuronal and immune stimuli for insulin secretion. Cell Reports, in press (2026)
  6. Huang, Y.C., Rupnik, M.S. and Rutter, G.A. Pancreatic alpha-cells are functionally heterogenous and sex-dependently regulated by neighboring endocrine cells. Commun Biol. 2026 Jun 23. doi: 10.1038/s42003-026-10163-6. Online ahead of print.
  7. Zhao, L., Hopley, S., Chien-Nien, C., Kibread, I., Xie, C., Baxan, N., Ashek, A., Fellows, A., Kostyunina, D., Oliver, E., Shu, N., Rutter, G.A., Gorelik, J., Gurrell, R., Butt, R., Hamblin, P., Wilkins, M.R. Targeting ZIP12-Mediated Zn²⁺ Signaling as a treatment for Pulmonary Hypertension.; Sci Advances accepted subject to minor textual revision (2026).
  8. Cherkaoui, I., Gasser, M., Du, Q., Egli, D.M., Dion, C., Leitch, H.G., Ostinelli, G., Bhatele, S., Sachedina, D., Misra, S. and Rutter, G.A. A recessive HNF1A p.A251T variant causes monogenic diabetes by altering islet cell development, insulin secretion and intercellular connectivity. In Press, Diabetologia (2026)

 

Review Article

  1. Ashcroft, F.M., Denton, R.M., Rorsman, P. and Rutter, G.A. “Stephen Ashcroft – an Obituary”.  Diabetologia, in press (2026)

 

Original Articles

  1. Brisnovali, N.F., Franco, I., Abdelgawwad, A., Tsou, H.L.P., Huy Cao, H., McDonald, J., Riva, A., Rutter, G.A.* and Akalestou, E. Effects of SGLT2 Ablation or Inhibition on Corticosterone Secretion in High-Fat-Fed Mice: Exploring a Nexus with Cytokine Levels. Diabetologia 68(9):2042-2056 2025 *corresponding author
  2. Li, J., Deng, Y., Gasser, M., Zhu, J., Walker, E.M., Sidarala, V., Reck, E.C., Hubers, D.L., Pasmooij., M.B., Shin, C-S., bandesh, K., Motakis, E., Nargund, S., Kursawe, R., Basrur, V., Nesvizhskii, A.I., Stitzel, M.L., Chan, D.C., Rutter, G.A. and Soleimanpour, S.A. LonP1 regulation of mitochondirla protein folding provides insights into beta cell failure in type 2 diabetes. Metab 7(8):1570-1592 (2025)
  3. Connelly, B., McCreight, L., Slieker, R.C., Bedair, K.F., Donnelly, L., de Klerk, J.A., Beulens, J.W.J., Elders, P.J.M., Bergstrom, G., Hong, M-G., Koivula, R.W., Franks, P.W., Schwenk, J.M., Gummerson, A., Pearson, E.R., t`hart, L.M., IMI-DIRECT, IMI-Rhapsody (including Rutter, G.A.). The influence of metformin treatment on the circulating proteome. EBioMedicine 118:105859 (2025)
  4. Ho, Q.W.C., Miller, J.A., Gunaseelan, D., Chelliah, R., Babu, H.J., Chew, X.Y., Devaraj, S., Tay, V.S., Kong, X., Wang, X., Tan, D.Y., Rutter, G.A., Lee, B., Teo, A.K.’., Ali, Y. I-BET151 modulates glucokinase gene expression and β-cell function in part through changes in FOXO1 expression. Diabetologia 68(12)2767-2780 (2025)
  5. He, S., Meister, D., Kahn, S., Mohammadzeh, A., Delgadillo da Silva, L., Rutter, G.A., Trant, J and Lim, G. A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: Repurposing drugs to disrupt 14-3-3 protein-BAD interactions. Cell Death Diff 16(1):825 (2025)

Review Articles

  1. Behrens, P., Champagne, C.M., Halford, J.C.G., Moodie, M., Mooney, V., Proietto, J., Rutter, G.A., Samara, K. and Holly, J.M.P. The obesity challenge: sicen and solutions – overlaps with the climate crisis, Frontiers in Science, in press (2025).
  2. Tang, A., Lepage, M., Rutter, G.A., Carpentier, A.C. Editorial: In vivo magnetic resonance imaging of metabolic disorders. Endocr 16:1713999 (2025)

Original Articles

  1. Cherkaoui, I., Du, Q., Egli, D., Misra, M and Rutter, G.A. Optimized Protocol for Generating Functional Pancreatic Insulin-secreting Cells from Human Pluripotent Stem Cells. Journal of Visualised Experiments (JoVe) 2(204) (2024)
  2. Slieker, R.C., Munch, M., Donnelly, L.A., Bouland, G., Dragon, I., Kuznetsov, D, Elders, P., Rutter, G.A., Ibberson, M., Pearson, E.R., ‘t Hart, L.M., van de Wiel, M.A., and Beulens, J.W.L. A multi-omics machine learning approach to predict diabetes progression: a RHAPSODY study. Diabetologia 7(5):885-894 (2024)
  3. Yu, V., Yong, F., Marta, A., Khadayate, S., Osakwee, A., Bhattacharya, S.S., Varghese, S.S., Chabosseau, P., Tabibi, S.M., Chen, K., Georgiadou, E., Parveen, N., Suleiman, M., Stamoulis, Z., Marselli, L., de Luca C., Tesi, M., Ostinelli, G., Delgadillo Silva, L., Wu, X., Hatanaka, Y., Montoya, A., Elliot, J., Patel, B., Demchenko, N., Wilding C., Hajkova, P., Schliaha, P., Kramer, H., Ali, Y., Marchetti, P., Sladek, R., Dhawan, S., Withers, D.J., Rutter, G.A.* and Millership, S.J. Establishment of beta cell heterogeneity via differential CpG methylation at Nnat. Diabetologia 67(6):1079-1094. (2024) * Co-corresponding author
  4. Li, S., Dragan, I, Tran, V.D.T., Fung, C.H., Kuznetsov, D., Hansen, M.K., Beulens, J.W.J., ’t Hart, L.M., Slieker, R.C., Donnelly, L.A., Gerl, M.J., Klose, C., Mehl, F., Simons, K., Elders, P.J.M., Pearson, E.P., Rutter, G.A.*. and Ibberson, M.* Multi-omics clusters associated with progression in type 2 diabetes: an IMI-RHAPSODY Study. Endo, 15:1350796. (2024) * Co-corresponding author
  5. Ghiasi, S.M., Marchetti, P., Piemonti, L., Nielson, J.N., Porse, B.Y., mandrup-Poulse, T., and Rutter, G.A. Proinflammatory Cytokines, but not Glucolipotoxicity, Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells. Endo. 15:1359147 (2024)
  6. Hu, M., Kim, I., Moran, I., Peng, W., Sun, O., Bonnefond, A., Bonas-Guarch, S., Froguel, P., Rutter, G.A. Multiple Genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β cell survival and function FASEB J 38(8):e23610 (2024).
  7. Cuozzo, F., Viloria, K., Shileh, A.H., Nasteka, D., Frazer-Morris, C., Tong, J., Jiao, Z., Boufersaoui, A., Marzullo, B., Rosoff, D.B., Smith, H.R., Bonner, C., Kerr-Conte, J., Pattou, F., Nano, R., Piemonti, L., Johnson, P.R.V., Speirs, R., Roberts, J., Lavery, G.G., Clark, A., Ceresa, C.D.L., Ray, D.W., Hodson, L., Davies, A., Rutter, G.A., Shima, M., Scharfmann, R., Merrins, J., Akermann, I., Tennant, D., Ludwig, C. and Hodson, D.J. LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic beta cells. Cell Reports 43(4):114047 (2024)
  8. Suba, K., Patel, Y., Roberts, A. Martin Alonso, A., Roberts, A., Hansen, B., Norton, M., Shrewsbury, J.V., Chen, S, Kwok, R., Kalogianni, V., Chen, S., Liu, X., Rutter, G.A., Jones, B., Minnion, J., Owen, B., Distaso, W., Drucker, D.J., Tan, M., Bloom, S.J., Murphy, K., Salem, V. Intra-islet glucagon regulates beta-cell connectivity, first phase insulin secretion and glucose homeostasis. Mol Metab 85:101947 (2024)
  9. Delgadillo Silva, L.F., Singh, S.P., Georgiadou, E., Rutter, G.A.* and Ninov, N. Optogenetic β cell interrogation in vivo reveals a functional hierarchy directing the Ca2+ response to glucose supported by vitamin B6. Science Adv 10(26):eado4513 (2024) * Co-corresponding author
  10. Manchanda, Y., ElEid, L., Oqua, A.I., Ramchunder, Z., Choi, J., Shchepinova, M.M., Rutter, G.A., Asuka Inoue, A., Tate, E.W., Jones, B., and Tomas, A. Engineered mini-G proteins block the internalization of cognate GPCRs and disrupt downstream intracellular signaling. Science Signalling, 17(843):eabq7038 (2024)
  11. Haberman, N., Cheung, R., Pizza, G., Cvetesic, N., Nagy, D., Maude, H., Blazqueez, L., Lenhard, B., Cebola, I., Rutter, G.A.* and Martinez-Sanchez, A. Liver kinase B1 (LKB1) regulates the epigenetic landscape of mouse pancreatic beta cells. FASEB J 38(16):e23885 (2024) *Co-corresponding author
  12. Carapeto, P., Jiho Kahng, J., Alves-Wagner, A.B., Middelbeek, R.J.W., Hirshman, M.F., Rutter, G.A. Goodyear, L.J., and Aguayo-Mazzucato, C. Exercise activates AMPK in mouse and human pancreatic islet leading to decreased senescence. Nature Metabolism 6(10):1976-1990 (2024)
  13. Lopez-Nogiega, L., Callingham, R.M., Martinez-Sanchez, A., Pizza, G., Haberman, N., Cvetesic, N., Nguyen-Tu, M.S., Lenhard, B., Marchetti, P., Piemonti, L., de Koning, E., Shapiro, A.M.J., Johnson, P.R., Leclerc, I. and Rutter, G.A. The long non-coding RNA Pax6os1/PAX6-AS1 modulates pancreatic cell beta cell identity and function. iScience, 28(1):111518 (2024).
  14. Dolgin, V., Chabosseau, P., Bistritzer, J., Noyman, I., Wormser, O., Eskin-Schwartz, M., Kanengisser-Pines, B., Narkis, G., Abramsky, R., Shany, E., Staretz-Chacam, Rutter, G.A., Birk, O.S. Severe neonatal hypotonia due to SLC30A5 variant affecting function of the encoded ZnT5 zinc transporter. JMID Reports 66(1):e12465 (2024)
  15. Manchanda, Y., Jones, B., Carrat, G., Ramchunder, Z., Marchetti, P., Leclerc, I., Thennati, R., Burade, V., Natarajan, M., Shahi, P., Tomas, A., and Rutter, G.A. Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion in vitro and in vivo of a Novel GLP1R-GIPR Dual Agonist, HISHS-2001. Diabetes, Obesity and Metabolism 27(10):5938-5949 (2024)

 

Review Articles

  1. Rutter, G.A. and Sweet, I.R. Glucose regulation of beta cell KATP channels: is a new model needed? Diabetes, 73(6):849-855 (2024).
  2. Rutter, G.A., Gresch, A., Delgadillo, L. and Benninger, R.K. Exploring pancreatic beta cell subgroups and their connectivity. Nature Metabolism 6(11):2039-2053 (2024)

Original Articles

  1. Slieker, R.C. A Donnelly, L.A., Akalestou, E., Lopez-Noriega, Livia, Melhem R., Güneş A., Abou Azar, F., Efanov, A., Georgiadou, E., Muniangi-Muhitu, H., Sheikh, M., Giordano, G.N., Åkerlund, M., Ahlqvist, E., Ali, A., Banasik, K., Brunak, S., Marko Barovic, M., Bouland, G.A., Burdet, F., Canouil, M., Dragan, I., JM Elders, P.J.M., Fernandez, C., Festa, A., Fitipaldi, H., Froguel, P., Gudmundsdottir, V., Gudnason, V., Gerl, M.J., A. van der Heijden, A.A., Jennings, L.L.,. Hansen, M.K., Kim, M., Leclerc I., Klose, C., Kuznetsov, D., Mansour Aly, D., Mehl, F., Marek, D., Melander, O., Niknejad, A., Ottosson, F., Pavo, I., Duffin, K., Syed, S.K., Shaw, J.L., Cabrera, O., Pullen, T.J., Simons, K., Solimena, M., Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Legido Quigley, C., Groop, L., Thorens, B., Franks, P.W., Lim, G.E., Estall, J.E., Ibberson, M., WJ Beulens, J.W.J., ’t Hart, L.M., Pearson, E.R. and Rutter, G.A. Identification of biomarkers for glycaemic deterioration in type 2 diabetes. Nat Comms, 14, 2533 (2023)
  2. Parizad E. Avari, P.E., Eng, P.C., Hu, M., Popovic, N., Polychronakos, C., Rutter, G.A., Oliver, N., Wernig, F. A novel somatic mutation implicates ATP6V0D1 in proinsulin processing. Endo. Soc. 7(3):bvac196 (2023)
  3. Chabosseau, P.L., Yong, S.W.F., Delgadillo-Silva, L.D., Lee, E.Y., Li, S., Gandhi, N., Wastin, J., Lopez, L., Leclerc, I., Ali, Y., Hughes, J.W., Sladek, R., Martinez-Sanchez, A., Rutter, G.A. A molecular signature of pancreatic islet leader beta cells using “Flash-Seq”. LifeSciences 316:121436 (2023)
  4. Surekha, M.V., Suneetha, N., Balakrisha, N., Kumar, P.U., Satyanarayana, K., Geddam, J.J.B., Sreenu, P., Tulja, B., Mamidi, R.S., Rutter, G.A., and Meur, G. Impact of COVID-19 on placental pathology, maternal and neonatal outcomes irrespective of hemoglobin status of term pregnant mothers. Endoc – Reprod, 14:1092104 (2023)
  5. Bitsi, S., Manchanda, Y., El Eid, L., Mohamed, N., Hansen, B., Suba, K., Rutter, G.A., Salem, V., Jones, B., Tomas, A. Divergent acute versus prolonged in vivo GLP-1R responses in β-arrestin 2-deleted primary beta cells. Science Advances 9(18):eadf7737 (2023)
  6. Xiao J, El Eid L, Buenaventura T, Boutry R, Bonnefond A, Jones B, Rutter, G.A., Froguel P, Tomas A. Control of human pancreatic beta cell kinome by glucagon-like peptide-1 receptor biased agonism. Diabetes Obes Metab. 25(8):2105-2119 (2023)
  7. Firth, G., Georgiadou, E, Griffiths, A., Amrahli, M., Kim, J., Yu, Z., Hu, M., Stewart, T.J., Leclerc, I., Okamoto, H., Gomez, D., Blower, P.J. and Rutter, G.A. Impact of an SLC30A8 loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice. Frontiers Endocrin, Diabetes: Molecular Metabolism, 14:1171933 (2023) doi: 10.3389/fendo.2023.1171933
  8. So, W.Y., Liao, Y, Nam Liu, W, Rutter, G.A., Han, W. Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy. EMBO Mol Med, e17928. (2023) doi: 10.15252/emmm.202317928

 

Review Articles

  1. Rutter, G.A., Sidarala, V., Kaufman, B.A. and Soleimanpour, S.A. Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing. Biochemical Society Sir Philip Randle Award lecture, 2023, Biochem J. 480(11):773-789 (2023)
  2. Thompson, P., Pipella, J., Rutter, G.A., Gaisano, H.Y., Santamaria, P. Islet autoimmunity in type 1 diabetes: initiation and progression from the perspective of the β cell. Diabetologia 66(11):1971-1982 (2023)

Original Articles

  1. Nguyen-Tu, M-S., Harris, J., Martinez-Sanchez, A., Chabosseau, P., Hu, M., Georgiadou, E., Pollard, A., Otero, P., Lopez-Noriega, L., Leclerc, I., Sakamoto, K., Schmoll, D., Smith, D.M., Carling, D., ajd Rutter, G.A. Opposing effects on regulated insulin secretion of acute versus chronic stimulation of AMP-activated protein kinase. Diabetologia 65(6):997-1011. doi: 10.1007/s00125-022-05673-x. Epub 2022 Mar 16.
  2. Karsai, M., Zuellig, R.A., Lehman, R.L., Hodson, D.J, Spinas, G.A., Rutter, G.A.*, and Gerber, P.A. Absence of zinc transporter ZnT8 protects pancreatic islet cells against hypoxia- and cytokine-induced cell death. J Endocrinol 253(1):1-11. doi: 10.1530/JOE-21-0271 (2022). *Co-corresponding author
  3. Zheng, X., Ho, Q.W.C., Chua, M., Steelmashenko, O., Muralidharan, S., Torta, F., Chew, E.G.Y., Lian, M.M., Foo, J.N., Rutter, G.A., Wenk, M., Silver, D.L., Berggren, O., and Ali, Y. Destabilization of β-cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes. Natl. Acad. Sci 119(11):e2113074119. doi: 10.1073/pnas.2113074119. Epub 2022 Mar 7. (2022)
  4. Pernaute, B., Perez-Montero, S, Sanchez-Nieto, J.M., di Gregorio, A., Lima, A., Lawlor, K., Bowling, S., Liccardi, G., Tomas, A., Meier, P., Sesaki, H., Rutter, G.A. Barbaric, I., and Rodriguez, T.A. Drp1 regulation of mitophagy determines the apoptotic response upon embryonic differentiation. Dev Cell 51(11) 1316-1330 (2022)
  5. Cao, H., Chung, A.C.K., Ming, X., Mao, D., Man Lee, H., Cao, X, Rutter, G.A., Chan, J.C.N., Tian, X.Y., and Kong, A.P.S. Autotaxin signaling facilitates β cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency. Mol Metab 60:101493 (2022)
  6. Georgiadou, E., Muralidharan, C, Martinez, M., Chabosseau, P., Tomas, A., Yong Su Wern, G., Stylianides, T., Wretland, A., Leguido-Quigley, C., Alsabeeh, N., Cruciani-Guglielmacci, C., Magnan, C., Ibberson, M., Leclerc, I., Ali, Y., Linnemann, A.K. Rodriguez, T.A., and Rutter, G.A. Mitofusins Mfn1 and Mfn2 are required in the β-cell to preserve glucose but not incretin induced beta cell connectivity and insulin secretion Diabetes 71(7)1472-1489 (2022)
  7. Cheung, R., Pizza, G., Chabosseau, P., Rolando, D., Tomas, A., Burgoyne, T., Wu, Z., Salowska, A., Tapa, A.,Macklin, A., Cao, Y., Nguyen-Tu, M.S., Dickerson, M.T., Jacobson, D.A., Marchetti, P., Shapiro, J., Piemonti, L., de Koning,E., Leclerc, I., Bouzakri, K., Sakamoto, K., Smith, D.M., Rutter, G.A. and Martinez-Sanchez, A. Glucose-dependent mir-125b is a negative regulator of β cell function. Diabetes 71(7)1525-1545 (2022)
  8. Akalestou, E., Lopez-Noriega, Iain Tough, Ming Hu, Leclerc, I., Helen C. Cox., and Rutter, G.A. Vertical Sleeve Gastrectomy lowers SGLT2 expression in the mouse kidney Diabetes 71(8)1623-1635 (2022)
  9. Cruciani-Guglielmacci, C., Meneyrol, K., Denom, J., Kassis, N., Rachdi, L., Makaci, F., Migrenne-Li, S., Daubigney, F., Georgiadou, E., Denis, R.G., Rodriguez Sanchez-Archidona, A., Paul, J-L., Thorens, B., Rutter, G.A., Magnan, C., Le Stunff, H., Janel, N. Homocysteine metabolism pathway is involved in the control of glucose homeostasis: a cystathionine beta synthase deficiency study in Mouse Cells 11(11):1737 (2022)
  10. Jones, B., Burade, V., Akalestou, E., Manchanda, Y., Ramchunder, Z., Carrat, G., Nguyen-Tu, M.-S., Marchetti, P., Piemonti, P., Leclerc, I., Thennati, R., Visboll, T., Thorens, B., Tomas, A and Rutter, G.A. In vivo and in vitro characterisation of GL0034, a novel long-acting GLP-1 receptor agonist Diabetes Obesity and Metabolism, 24(11):2090-2101 (2022)
  11. Bosi, I., Marchetti, P., Rutter, G.A., Eizirik, D.L. Gene signatures of human alpha cells in types 1 and 2 diabetes indicate disease-specific pathways of alpha cell dysfunction. iScience 25(10):105056. (2022)
  12. Akalestou, E., Lopez-Noriega, L., Christakis, I., Hu, M., Miras, A.D., Leclerc, I., and Rutter, G.A. Vertical Sleeve Gastrectomy normalizes glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice. Endo. 13:1020576. (2022)
  13. Sui, K., Du, Q., Romer, A., Su, Q., Chabosseau, P.L., Xin, P., Xin, Y., Kim, Y., Kleiner, S., Rutter, G.A. and Egli, D. Loss of function mutation in ZnT8 increases resistance of human embryonic stem cell-derived beta cells to apoptosis in low zinc condition. Cells 12(6)903 (2022)

 

Review Articles

  1. Akalestou, E., Miras, M.D., Rutter, G.A. and le Roux, C. W. Mechanisms of weight loss after obesity surgery. Endo Rev. 43(1):19-34 (2022)
  2. Anindya, R. Rutter, G. Meur, G. New onset type 1 diabetes and severe acute respirator syndrome coronavirus 2 infection. Immunology and Cell Biologie 101(3):191-203 (2022)

Original Articles

  1. Mousavy-Gharavy, N., Owen, B.M., Millership, S.J., Chabosseau, P., Pizza, G., Martinez-Sanchez, A., Tasoez, E., Georgiadou, E., Hu, M., Fine, N.H.F., Jacobson, D.A., Dickerson, M.T., Idevall-Hagren, O., Montoya, A., Kramer, H., Mehta, Z., Withers, D., Ninov, N., Gadue, P.J., Cardenas-Diaz, F.L., Cruciani-Guglielmacci, C., Magnan, C., Ibberson, M., Leclerc, I., Voz, M., Rutter, G.A. Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis. Diabetologia, 64(4):850-864 (2021)
  2. Nasteska, D., Fine, N.H.F., Ashford, F.B., Smith, G., Bakht, M., Bastida-Ponce, A., Rutter, G.A., Fiancette, R., Nano, R., Piemente, L., Lickert, H., Zhou, Q., Akerman, I., Hodson, D.J. PDX1LOW MAFALOW b-cells contribute to islet function and insulin release. Nature Comms, 12(1):674 (2021)
  3. Ming, X., Chung, A.C.K., Mao, D., Cao, H., Fan, B., Wong, W.K.K., Ho, C.C., Lee, H.M., Schoonjans, K., Auwerx, J., Rutter, G.A., Chan, J.C.N., Tian, X.Y., Kong, A.P.S. Pancreatic sirtuin 3 deficiency promotes hepatic steatosis by enhancing 5-hydroxytrypatamine synthesis in diet-induced obese mice. Diabetes, 70(1):119-131 (2021)
  4. Hu, M., Cebola, I., Carrat, G., Jiang, S., Nawaz, S., Khamnis, A., Canouil, M., Froguel, P., Schulte, A., Solimena, M., Ibberson, M., Marchetti, P., Cardenas-Diaz, F.L., Gadue, P.J., Hastoy, B., Almeida-Souza, L., McMahon, H., Rutter, G.A. Chromatin 3D interation analysis of the STARD10 locus unveils FCHSD2 as a new regulator of insulin secretion. Cell Reports 34(5):108703. (2021)
  5. Slieker, R.C., Donnelly, L.A., Fitapaldi, H., Bouland, G., Giordano, G.N., Akelund, A., Gerl, M.J., Ahlqvist, EE., Dragon, I., Festa, A., Hansen, M.K., Mansour, D., Kim, Min, Kuznetsov, D, Mehl, F., Klose, C., Simons, K., Pavo, I., Pullen, T.J., Suvaital, T., Wretland, A., Rossing, P., Lysseenko, V., Legido Quigley, C., Groop, L., Thoresnee, B., Franks, P.W., Ibberson, M., Rutter, G.A., Beulens, J.W.L., ‘r Hart, L.M. and Pearson, E.R. Replication and cross-validation of T2D subtypes based on Clinique variables: an IMI-RHAPSODY study. Diabetologia 64(9):1982-1989 (2021)
  6. Parks, S., Gao, T., Jimenz Awuapura, N., Ayathamattam, J., Chabosseau, P.L., Kalvakolanu, D., Valdavia, H.H., Rutter, G.A., Leclerc, I., Sorcin stimulates Activation Transcription Factor 6 (ATF6) transcriptional activity. FEBS Lett, 595(13):1782-1796 (2021)
  7. Akalestou, E., Suba, K., Lopez-Noriega, L., Georgiadou, E., Chabosseau, P., Gallie, A., Wretland, A., Quigley, C., Leclerc, I., Salem, V. and Rutter, G.A. Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice. Nat Comms, 2(1):5165. doi: 10.1038/s41467-021-25423-8 (2021) https://www.nature.com/articles/s41467-021-25423-8
  8. de Jesus, D., Mak, T.C.S., Wang, Y-F., von Ohlen, Y., Bai, Y., Kane, E., Chabosseau, P., Chahrour, C.M., Distaso, W., Salem, V., Tomas, A.T., Stoffel, M., Rutter, G.A., Latreille, M. Dysregulation of a Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes. Mol Metab, 53:101248 (2021)
  9. So W.Y., Teo, A.K.K., Rutter, G.A., and Han, W. Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis. Sci Transl Med 13(600) (2021)
  10. Marzook, M., Chen, S., Pickford, P., Lucy, M., Wang, Y., Correa, I., Briochhagen, J., Hodson D.J., Salem, V., Rutter, G.A., Tan, T., Bloom, S.R., Tomas, A, Jones, B. Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1. Biochem Pharmacol 190:114656 (2021)
  11. Jha, M.K., Ament, X.H., Yang, F., Vidensky, S., Collins, S.L., Horton, M.R., Hoke, A., Rutter, G.A., Rothstein, J.D. and Morrison, B. Immunometabolic reprogramming of macrophages by targeting MCT1 promotes nerve regeneration. J Clin Invest 70(11):2683-2693 (2021)

 

Review Articles

  1. Lopez-Noriega, L. and G.A. Long non-coding RNAs as modulators of pancreatic β-cell mass and function. Front. Endo 11:610213 (2021)
  2. Chabosseau, P., Rutter, G.A., and Millership, S.J. Importance of both Imprinted genes and functional heterogeneity for pancreatic beta cell function. Int J Mol Sci. 22(3):1000(2021)
  3. Ghiasi, S.M. and Rutter, G.A. Consequences for pancreatic beta cell identity and function of unregulated transcript processing. Front Endocrinol. 12:625235 (2021)

Original Articles

  1. Georgiadou, E., Haythorne, E., Pullen, T.J., da Silva Xavier, G., Martinez-Sanchez, A., Semplici, F., Rizzuto, R., McGinty, J.A., French, P.M., Cane, M.C., Leclerc, I., Rutter, G.A., The mitochondrial Ca2+ uniporter MCU is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice Diabetologia 63(7):1368-1381. (2020)
  2. Ralston, J.C., Nguyen-Tu, M-S., Lyons, C.L., Murphy, A.M., Cooke, A.A., Falvey, A., Finucane, O.M., Rutter, G.A. and Roche, H.M. A dietary switch from saturated to monounsaturated fat reduces hyperinsulinemia and partially protects against pancreatic islet dysfunction in mice. Br J Nutrition ‏124 (3), 247-255 (2020)
  3. Clough, T.J., Baxan, N., Coakley, E.J., Rivas, C., Leclerc, I., Zhao, L., Martinez-Sanchez, A., Rutter, G.A. and Long, N.J. Synthesis ad in vivo behaviour of an exendin-4-based MRI probe capable of β-cell dependent contrast enhancement in the pancreas. Dalt Trans 49(15):4732-4740 (2020)
  4. Fang, Z., Chen, S., Pickford, P., Broichhagen, J., Hodson, D., Correa, I., Kumar, S., Görlitz, F., Dunsby, C., French, P., Rutter, G.A., Tan, T., Bloom, S.R., Tomas, A. Jones, B.The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists ACS Pharmacol & Tran Sci 3(2):345-360 (2020).
  5. Ma, Y., Ratnasabapathy, R., De Backer I., Izzi-Engbeaya, C., Nguyen-Tu, M.S., Shillito, J.C., Lam, B.Y.H., Rutter, G.A., Yeo, J., Dhillo, W.S., Gardiner, J. Glucokinase within the hypothalamic paraventricular nucleus has a critical role in the regulation of GLP-1 release. JCI Insights 5(8):e132760 (2020)
  6. Lucey, M., Pickford, P, Minnion, J., Ungewiss, J., Schoenberg, K., Rutter, G.A., Bloom, S.R., Tomas, A. and Jones, B. Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists. Mol Metab 37:100991 (2020)
  7. Carrat, G.C., Haythorne, E., Tomas, A., Haataja, L., Muller, A., Arvan, P., Piunti, A., Cheng, K., Huamg, M., Pullen, T.J., Geoergiadou, E., Stylianedes, T., Amirruddin, N.S., Salem, V., Disatso, W., Cakebread, A., Heesom, K.J., Lewis, P.A., Hodson, D.J., Briant, L.J., Fung, A., Sessions, R.B., Alpy, F., Kong, A., Benke, P.I., Torte, F., Teo, A.K.K., Leclerc, I., Solimena, M., Wigley, D.B., and Rutter, G.A. The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis. Mol Metab. 40:101015 (2020)
  8. Mostafa, D., Yanagiya, A., Georgiadou, E., Wu, Y., Stylianides, T., Rutter, G.A., Suzuki, T. and Yamamoto, T. CCR4-NOT complex/CNOT3 is essential for maintain/establishing β cell identity through repression of β cell disallowed genes. Biol 3(1):476. (2020)
  9. Amouyal, C., Castel, J., Guay, C., Lacombe, A., Denom, J., Migrenne-Li, S., Rouault, C., Marquet, F., Georgiadou, E., Stylianides, T., Luquet, S., Le Stunff, H., Scharfmann, R., Clement, K., Rutter, G.A., Taboureau, O., Magnan, C, Regazzi, R. and Andreelli, F. Bariatric surgery regulates multiple beta cell pathways during resolution of diabetes. EBioMedicine 58:102895 (2020)
  10. Mao, D., Tian, X.Y., Jiang, G., Mao, D., Wang, C.C., Lau, C.B.S., Lee, H.M., Wong, C.K., Chow, E., Xing, M., Tam, C., Ma, R.C.W., Rutter G.A., Kong, A.P.S., Tam, W.H., and Chan, J.C.N. Maidong polysaccharide extract increases insulin secretion and reduces IL-1β-induced islet inflammation partially though inhibition of IKK in the NFKB pathway. J Biol Chem 295(36):12573-12587 (2020)
  11. Nguyen-Tu, M-S., Martinez-Sanchez, A., Leclerc, I., Rutter, G.A. and da Silva Xavier, G. Adipocyte-specific deletion of TCF7L2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice. Diabetologia, 64(1), 129-141 (2020)
  12.  

Review Articles

  1. Khan, R., Tomas, A. and Rutter, G.A. Effects on Pancreatic Beta and other Islet Cells of the Glucose-dependent Insulinotropic Polypeptide. Peptides, 125:170201 (2020)
  2. Georgiadou, E. and Rutter, G.A. Highlight: Yau et al A fluorescent timer reporter enables sorting of insulin secretory granules by age. Biol. Chem 295(27):8912-8913 (2020)
  3. Rutter, G.A., Ninov, N, Salem, V., Hodson, D.J. Comment on “Take me to your leader: an electrophysiological appraisal of the role of hub cells in pancreatic islets” by Satin et al. Diabetes 69(5):830-836 (2020)
  4. Rutter, A., McCormack, J.G., Halestrap, A.P. and Denton, R.M. The roles of cytosolic and intramitochondrial Ca2+ and the mitochondrial Ca2+-uniporter (MCU) in the stimulation of mammalian oxidative phosphorylation eLetter, J. Biol Chem, 295(30):10506 (2020)
  5. Georgiadou, E., and Rutter, G.A. Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells. Cell Calcium. 91:102282 (2020)
  6. Muniangi-Muhitu, H., Akalestou, E., Salem, V., Misra, S., Oliver, N.S., Rutter, G.A. Covid-19 and diabetes: a complex bidirectional relationship. Endo. 11:582936 (2020)
  7. Rutter, G.A., Georgiadou, E., Martinez-Sanchez, A. and Pullen, T.J. Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity. 63(10):1990-1998 (2020)
  8. Hu, M., Cherkaoil, I., Misra, S. and Rutter, G.A. Functional genomics in pancreatic β cells: recent advances in gene deletion and genome editing technologies for diabetes research. Front Endo. 11:576632 (2020)

Original Articles

  1. Anzilotti, C., Swan, D., Boisson, B., Deobagkar-Lele, M., Chabosseau, P., Engelhardt, K., Xu, X., Chen, R., Alverez, L., Berlinguer-Palmini, R., Bull, K., Cawthorne, E., Cribbs, A., Crockford, T.L., Dang, T.S., Fearn, A, Fenech, E., de Jong, S.J., Lagerholm, B.C., Ma, C.S., Sims, D., Van Den Berg, B., Xu, Y., Cant, A.J., Kleiner, G., Leahy, T.R., de la Morena, M.T., Puck, J.M., Shapiro, R.S., van der Burg, M., Chapman, J.R., Christianson, J.C., Davies, B., McGrath, J.A., Przyborski, S., Santibanez, K., M. Santibanez Koref, M., Tangye, S.G., Werner, A., Rutter, G.A., Padilla-Parra, S., Casanova, J.L., Cornall, R.J., Conley, M.E. and Hambleton, S. An essential role for the Zn2+ transporter ZIP7 in B cell development. Nature Immunol 20(3):350-361 (2019)
  2. Salem, V., Delgadillo Silva, L-F., Suba, K., Georgiadou, E., Mousavy, N., Akhtar, N., Martin-Alonso, A., Gaboriau, D.C.A., Rotheray, S., Stylianides, T., Carrat, G.C., Pullen, T.J., Pal Singh, S., Hodson, D.J., Leclerc, I., Shapiro, A.M. James, Marchetti, P., Briant, L.J.B., Distaso, W., Ninov, N. and Rutter, G.A. Leader beta cells coordinate Ca2+ dynamics across pancreatic islets in vivo. Nature Metabolism 1, 625-629 (2019) https://www.nature.com/articles/s42255-019-0075-2
  3. Buenaventura, T., Laughlin, W.E., Bitsi, S., Burgoyne, T., Lyu, Z., Oqua, A.I., Norman, H., McGlone, E., Klymencko, A.S., Correa, I.R., Walker, A., Inoue, A., Hanyaloglu, A., Rutter, G.A., Bloom, S.R., Jones, B., Tomas, A. Agonist-induced membrane nanodomain clustering determines GLP-1 receptor responses in pancreatic beta cells. PLoS Biol, 17(8):e3000097 (2019)
  4. Davis, S.P.X., Kumar, S., Alexandrov, Y., Bhargava, A., da Silva Xavier, G., Rutter, G.A., Frankel, P., Sahai, E., Flaxman, S., French, P.M.W. and MJcGinty, J. Convolutional neural networks for reconstruction of undersampled optical projection tomographyu data applied to in vivo imaging of zebrafish. Biophotonics DOI: 10.1002/jbio.201900128 (2019)
  5. Dwivedi, O.P., Lehtorvita, M., Hastoy, B., Chandra, V., Kleiner, S., Jain, D., Richard, A-M., Beer, N., Krentz, N.A.J., Prasad, R.B., Hansson, O., Ahlqvist, E., Krus, U., Artner, I., Gomez, D., Baras, A., Abaitua, F., Champon, B., Payne, A.J., Moralli, D., Thomsen, S.K., Kramer, P., Spiliotis, I., Ramracheya, R., Chabosseau, P., Theodoulou, A., Cheung, R., can de Bunt, M., Flannick, J., Trombetta, M., Bonara, E., Wollheim, C.B., Sarelin, L., Bonadonna, R.C., Rorsman, P., Davies, B., Brosnan, J., McCarthy, M.I., Otonkoski, T., Lagerstedt, J.O., Rutter, G.A., Gromada, J., Gloyn, A.L., Tuomi, T. and Groop, L. Loss of ZnT8 function protects against diabetes by enhanced insulin secretion. Nature Genetics, 51(11):1596-1606. (2019)
  6.  
  7.  

Review Articles

  1. Da Silva Xavier, G., and Rutter, G.A. Metabolic and functional heterogeneity in pancreatic β cells. For J Mol. Biol, special edition “Islet Biologie in type 2 diabetes” Eds, Gaisano, H., Jonas, J.C., and Gloyn, A. (2019b uenaventura) Aug 13. pii: S0022-2836(19)30508-X. doi: 10.1016/j.jmb.2019.08.005. (2019)
  2. Marchetti, P., Schulte, A., Marselli, L., Schonger, E., Bugliani, M., Kramer, W., Overburgh, L., Ullrich, S., Gloyn, A., Ibberson, M., Rutter, G.A, Froguel, P., Groop, L., McCarthy, M., Eizirik, D.L., Mathieu, C., Cnop, M., Thorens, B., Solimena, M. Fostering improved human islet research – A European Perspective. Diabetologia 62(8):1514-1516 (2019)
  3. Rutter G.A. Pancreatic Islet Secretion: Gabbling via GABA. News and Views article for Nature Metabolism. 1(11):1032-1033 (2019)

Original Articles

  1. Solimena, S., Schulte, A.M., Marselli, L., Ehehalt, F., Richter, D., Kleeberg, M., Mziaut, H., Knoch, K-P, Parnis, J., Bugliani, M., Siddiq, A., Joms, A., Burdet, F., Liechti,R., Suleiman, M., Margerie, D., Syed, F., Distler, M., Grützmann, R., Petretto, E., Moreno-Moral, A., Wegbrod, C., Sönmez,A., Pfriem, K, Friedrich, A., Meinel, Jörn, Wollheim, C.B., Baretton, G., Scharfmann, R., Nogoceke, E., Bonifacio, E., Sturm, D., Meyer-Puttlitz, B., Boggi, U., Saeger, H-D, Filipponi, F., Lesche, M., Meda, P., Dahl, A., Wigger, L., Xenarious, I., Falchi, M., Thorens, B., Weitz, J., Bokvist, K., Lenzen, S., Rutter, G.A., Froguel, P., von Bülow, M., Ibberson, M. and Marchetti, P. Systems Biologie of the IMIDIA biobank from organ donors and pancreatectomized patients defines the transcriptomic signature of type 2 diabetes. Diabetologia 61(3):641-657 (2018)
  2. Fine, N.H.F., Doig, C.L., Elhassan, Y., Marchetti, P., Bugliani, M., Piemonti, L., Rutter, G.A., Jacobson, D, Lavery, G.G. and Hodson, D.J. Glucocorticoid reprograms beta cell signalling to preserve insulin secretion. Diabetes 67(2):278-290 (2018)
  3. Martinez-Sanchez, A., Nguyen-Tu, M.S., Cebola, I., Yavari, A., Marchetti, P., Piemonti, L., de Koning, E., Shapiro, A. J., Johnson, P., Sakamoto, K., Smith, D.M., Leclerc, I., Ashrafian, A., Ferrer, J., and Rutter, G.A. miR-184 expression is regulated by AMP-activated protein kinaes (AMPK) in pancreatic islets. J. Jan 8:fj201701100R. doi: 10.1096/fj.201701100R (2018)
  4. Buenaventura, T., Kanda, N., Douzenis, P.C., Ben Jones, Stephen R. Bloom, Chabosseau, P., Correa, I.R., Bosco, D., Piemonti, L., Marchetti, P., Johnson, P.R., Shapiro, AM J, Rutter, G.A. and Tomas, A. A targeted RNAi screen identifies endocytic trafficking regulators of glucagon-like peptide-1 receptor responses in pancreatic beta cells. Diabetes 67(3):385-399 (2018)
  5. Tuncay, E., Verda Bitirim, C., Olgar, Y., Durak, A., Akar, A.R., Rutter, G.A. and Turan, B. Zn2+tranporters ZIP7 and ZnT7 partly localise to mitochondria and contribute to cellular Zn2+ muffling in mammalian heart under pathological conditions. Mitochondrion J pii: S1567-7249(17)30261-1. (2018)
  6. Jones, B., Buenaventura, T., Kanda, N., Chabosseau, P., Owen, B.M., Scott, R., Goldin, R., Angkathunyakul, N., Corrêa, I.R. Jr, Bosco, D., Johnson, P.R., Piemonti, L., Shapiro, A.M.J., Cochran, B.J., Hanyaloglu, A.C., Inoue, A., Tan, T., Rutter, G.A.*, Tomas, A. and Bloom, S.R. Targeting GLP-1 receptor trafficking to improve agonist efficacy. Nat Comms, 9(1):1602 (2018). *Co-corresponding author https://www.nature.com/articles/s41467-018-03941-2
  7. Janjuha, S., Paal Singh, S., Tasakmaki, A., Mousavy Gharavy, S.N., Murawala, P., Konantz, J., Birke, S., Hodson, D.J., Rutter, G.A., Bewick, G.A. and Ninov, N. Age-related Islet Inflammation Marks the Proliferative Decline of Pancreatic Beta-cells in Zebrafish. eLife pii: e32965. doi: 10.7554/eLife.32965 (2018)
  8. Ma, Y., Ratnasabapathy, R., Izzi-Engbeaya, C., Nguyen-Tu, M.S., Richardson, E., Hussain, S., De Backer, I., Holton, C., Rutter, G.A., Dhillo, W.S. and Gardiner, J. Arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis. Diabetes, Obesity and Metabolism 20(9):2246-2254 (2018)
  9. Millership, S.J., da Silva Xavier, G., Irvine, E.E., Choudhary, A.I., Bertazzo, S., Chabosseau, P., Pedroni, S.M.A., Irvine, E.E., Montoya, A., Faull, P., Taylor, W.R., Kerr-Conte, J., Pattou, F., Ferrer, J., Christian, M., John, R.M., Latreille, M., Liu, M., Rutter, G.A., Scott, J., and Withers, D.J. Neuronatin regulates insulin processing and secretion in response to glucose. J Clin Invest, 128(8):3369-3381 (2018)
  10. Kleiner, S, Gomez, D., Bhavsar, R., Na, Erqian, Cavino, K., Megra, B., Rojas, J., Zambrowicz, B., Carrat, G., Chabosseau, P., Hu, Ming, Murphy, A.J., Yancoppoulos, G.D., Rutter, G.A., Gromada, J. The human SLC30A8 R138X mutation promotes insulin secretion and beta cell proliferation in mice. Proc Nat Acad Sci, 115 (32):E7642-E7649 (2018)
  11. Izzi-Engbeaya, C., Comnios, A.N., Clarke, S., Jomard, A., Yang, L., Jones, S., Abbara, A., Narayanaswamy, S., Eng, P.C., Papadopoulou, D., Prague, J.K., Bech, P. Godsland, I.F., Bassett, P., Sands, C., Gomez Romero, M., Pearce, J.T.M., Lewis, M.R., Holmes, E., Nicholson, J.K., Tan, T., Ratnasabapathy, R., Hu, M., Carrat, G., Piemonti, L., Bugliani, M., Marchetti, P., Johnson, P.R., Hughes, S.J., Rutter, G.A. and Dhillo, W.S. Kisspeptin enhances glucose-stimualted insulin secretion and modulates the metabolic profile in humans – a finding with translational implications. Diabetes Obesity and Metabolism, 20(12):2800-2810 (2018)
  12. Kimura, T., Obtata, A., Shimoda, M., Shimuza, I., da Silva Xavier, G., Okauchi,S., Hirukawa, H., Kohara, K., Mune, T., Moriuchi, S., Hiraoka, A., Tamura, K., Chikazawa, G., Ishida, A., Yoshitaka, Rutter, G.A., Kaku, Kaneto, H. and Down regulation of vascular GLP-1 receptor expression in human subjects with obesity. Sci Rep 8(1):10644 (2018)
  13. Nguyen-Tu, M-S., da Silva Xavier, G., Lecler, I and Rutter G.A. Transcription factor Tcf7l2 acts downstream of protein kinase Lkb1/Stk11 to control beta cell growth and insulin secretion. J Biol Chem 292(21):8892-8906 (2018)
  14. Suwandhi, L., Hausmann, S., Braun, A., Gruber, T., Heinzmann, S.S., Galvez, E.L.C., Buck, A., Israel, A., Feuchtiner, A., Haythorne, E., Staiger, H., Heni, M., Haring, H-U., Schnitt-Kopplin, P., Kopplin, Schmitt-Kopplin, P., Walch, A., Garcia Caceres, C., Tschop, M., Rutter, G.A., Stowig, T., Elsner, M., Ussar, S. Chronic D-serine supplementation impairs insulin secretion. Mol Metab 16:191-202 (2018)
  15.  
  16.  

Review Articles

  1. Martinez-Sanchez, M., Nguyen-Tu, M-S., Leclerc, I. and Rutter G.A. Manipulation and measurement of AMPK activity in pancreatic islets. Methods Biologie Moléculaire 1732, 413-431 (2018)
  2. Jones, B., Bloom, S.R., Buenaventura, T., Tomas, A., and Rutter G.A. Control of insulin secretion by GLP-1. Peptides, Special Issue: anti-diabetic Ed.s Flatt, P.R. and Conlon, J.M. Elsevier (2018)
  3. Jenkins, A., Lengyel, I., Rutter, G.A., Loew, N., Shai, I., Tirosh, A., Petro, T., Khanaisi, M., Anndrews, S., Znora, N., Gross, A., Maret, M., LLewis, W. and Moran, A. Obesity, diabetes and zinc: a workshop promoting knowledge and collaboration between the UK and Israel Nov 28-30, 2016 – J. Trace Elem Met Biol. (Zinc-Net Special Issue); 49:79-85 (2018)
  4. Chabosseau, P., Woodier, J., Cheung, R. and Rutter, G.A. Control of subcellular zinc pools in health and disease. Metallomics, 10(2):229-239 (2018)
  5. Gromada, J, Chabosseau, P and Rutter G.A. The α-cell in diabetes mellitus. Nat Rev Endocrinol. 4(12):694-704 (2018)
  6. Benninger, R., Dorreell, C., Hodson, D.J., Rutter, G.A. The impact of pancreatic β cell heterogeneity on the pathogenesis of type 1 diabetes. Curr Diab Rep 18(11):112 (2018)

Original Articles

  1. Perez, Y., Shorer, Z., Leibson, K.,Chabosseau, P., kadir, R., Voloarsky, M., Halperin, D., Barber-Zucker, S., Shalev, H., Schreiber, R., Gradstein, L., Zarivach, R., Rutter, G.A., Landay, D., Birk, O.S. SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome of neurodevelopmental regression with oculomotor apraxia and early onset nephropathy. Brain 140(4):928-939 (2017)
  2. Carrat, G.R., Hu, M., Nguyen-Tu, M.S., Chabosseau, P., Gaulton, K., van de Bunt, M., Siddiq, A., Falchi., M., Thurner, M., Leclerc, I., Pullen, T.J., Cane, M.C., Prabhala, P., Schulte, A., Marchetti, P., Ibberson, M., MacDonald, P., Manning-Fox, J.E., Gloyn, A. L., Froguel, P., Solimena, M., McCarthy, M.I. and Rutter, G.A. Decreased STARD10 expression is associated with defective insulin secretion in humans and mice. Am J Hum Gen 100(2):238-256. (2017)
  3. Cruciani-Guglielmacci, C., Bellini, L., Denom, J., Oshima, M., Fernandez, N., Normandie-Levi, P., Berney, X.P., Kassis, N., Rouch, C., Dairou, J., Gorman, T., Smith, D.M., Marley, A., Liechti, R., Kuznetsov, D., Wigger, L., Burdet, F., Lefevre, A-L., Werlhe, I., Uphues, I., Hildebrandt, T., Rust, W., Bernard, C., Ktorza, A., Rutter, G.A., Scharfmann, R., Xenarios, I., Le Stunff, H., Thorens, B., Magnan, C. and Ibberson, I. Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion. Mol Metab 6(4):340-351 (2017)
  4. da Silva Xavier, G., Mondragon, A., Mouougavelou, V., Cruciani-Guglielmacci, C., Denom, J., Herrera, P.L., Magnan, C., Rutter G.A. Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses in mice. Diabetologia 60(6):1043-1050 (2017)
  5. Tuncay, E., Bitirim, V, Durak, A., Carrat, G.R.J., Taylor, K.., Rutter G.A.* and Turan, B. Hyperglycemia-induced changes in ZIP7 and ZnT7 expression cause Zn2+ release from the sarco(endo)plasmic reticulum and mediate ER stress in the heart. Diabetes 66(5):1346-1358 (2017) *Co-corresponding author
  6. Mehta, Z.B., Johnston, N.R., Nguyen-Tu, M-S., Broichhagen, J., Schultz, P., Larner, D.P., Leclerc, I., Trauner, D., Rutter, G.A.* and Hodson D.J. Remote control of glucose homeostasis in vivo using photoPharmacologie. Sci Rep. 7(1):291 (2017) *Co-corresponding author
  7. Pullen, T.J., Huising, M.O. and Rutter, G.A. Analysis of purified α and β cell transcriptomes reveals 11-hydroxysteroid (Hsd11b1) as a novel β cell disallowed gene. Frontiers in Genetics 8:41 (2017)
  8. Mitchell, R.K. Nguyen-Tu, M-S, Chabosseau, P., Callinghamn, R.M., Pullen, T.J., Cheung, R., Leclerc, I, Hodson, D.J. and Rutter, G.A. The transcription factor Pax6 is required for pancreatic beta cell identity, glucose-regulated ATP synthesis and Ca2+ dynamics in adult mice. J Biol Chem 292(21):8892-8906 (2017)
  9.  

Review Articles

  1. Martinez-Sanchez, A., Rutter, G.A., and Latreille, M. miRNAs in β-cell development, identity and disease. Frontiers in Genetics, 7:226 (2017)
  2. Rutter G.A. Controllng the identity of the adult pancreatic β cell. Nature Reviews Endocrinol 13(3):129-130 (2017)
  3. Rutter G.A. GABA signalling: a route to new β cells in type 1 diabetes. Cell Research 27(3):309-310 (2017) doi:10.1038/cr.2017.20
  4. Rutter, G.A. Hodson, D.J. Chabosseau, P., Haythorne, E., Pullen, T.J. and Leclerc, I. Local and regional control of calcium dynamics in the pancreatic islet. Diabetes Obesity and Metabolism 19 Suppl 1:30-41 (2017)

Original Articles

  1. Marmugi, A., Parnis, J., Chen, Xi, Carmichael, Hardy, J., Mannan, N., Marchetti, P., Piemonti, L., Bosco, D., Johnson, P., A.M. James Shapiro, Cruciani-Guglielmacci, C., Mangnan, C., Thorens, B., Ibberson, M. Valdivia, H.H., Rutter, G.A.* and Leclerc, I.* Sorcin links pancreatic β-cell lipotoxicity to ER Ca2+ Diabetes 65(4):1009-21 (2016)
  2. Sayers, S.R., Reimann, F., Gribble, F.M., Parker, H., Zac-Varghese, S., Bloom, S.R., Foretz, M., Viollet, B and Rutter, G.A. Proglucagon promoter Cre-mediated AMPK deletion in mice increases circulating GLP-1 levels and oral glucose tolerance. PLoS One, 1371/journal.pone.0149549 (2016)
  3. Martinez-Sanchez, A., Pullen, T.J., Chabosseau, P, Zhang, Q, Haythorne, L, Sayers, S. Cane, M.C., Nguyen-Tu, M-S, and Rutter, G.A. Disallowance of Acot7 in β-cells is required for normal glucose tolerance and insulin secretion. Diabetes, 65(5):1268-82 (2016)
  4. Broichagen, J., Johnston, N.R., Ohlen, Y. von, Meyer-Berg, H., Jones, B.J., Bloom, S.R., Rutter, G.A., Trauner, D and Hodson D.J. Allosteric photocontrol of a class of B G protein-coupled receptor. Angewandte Chemie, 55(19):5865-8 (2016)
  5. Denton, R.M., Pullen, T.J., Armstrong, C.T., Heesom, K.J. and Rutter G.A. Calcium-insensitive splice variants of mammalian E1 subunit of the 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression. J. 473(9):1165-78 (2016)
  6. Frank, JA, Yuschenko, D.A., Hodson D.J., Lipstein, N., Nagpal, J., Rutter, G.A., Rhee, J-S., Gottschalk, A., Schultz, C. and Trauner, D. Photoswitchable diacylglycerols enable optical control of protein translocation, PKC activity and vesicle release. Nat Chem Biol, 12(9):755-62 (2016)
  7. Yavari, A., Stocker, C.J., Ghaffari, S., Wargnet, E.T., Steeples, V., Czibik G., Bellahcene, M., Woods, A., Martinez de Morentin, P.B., Cansell, C., Lam, B.Y., Petkevikus K., Nguyen-Tu, M.S., Martinez-Sanchez, A., Pullen, T.J., Stockenhuber, A., Nguyen, C., Lazdamn M., Puliyadi, R., Kyriakou, T., Harper, A.R., Edwards, A., O’Dowd, J.F., Harikumar, P., Toth, M., Oliver, P.L., Brown, L.A., Beall, C., Chuster, A., Gandra, S., Sarabanda, A., Poncio, V., de Oliveira Figueiredo, M.J., Pinter, K., Redwood, C., Peirson, S.N., McCrimmon, R.J., Fekete, C., Yeo, G.S., Heisler, L.K., Rutter, G.A., Smith, M.A., Withers, D.J., Carling, D., Sternick, E.B., Arch, J.R.S., Cawthorne, M.A., Watkins, H., Ashrafian, H. Chronic activation of γ2 AMPK induces obesity and reduces beta cell function. Cell Metabolism, 23(5):821-36 (2016)
  8. Semplici, F., Mondragon, A., Macintyre, B., Madeyski-Bengtson, K., Persson-Kry, A., Ramne, A., Marley, A., McGinty, J., French, P., Soedling, H., Gaitan, J., Lang, J., Migrenne-Li, S., Philippe, E., Herrera, PL, Magnan, C., da Silva Xavier, G., and Rutter G.A. Cell-type specific deletion reveals roles of Per-Arnt-Sim (PAS) kinase in insulin and glucagon production. Diabetologia, 59(9):1938-47 (2016)
  9. Johnston, N.R., Mitchell, R.K., Haythorne, E., Pessoa, Maria Paiva, Semplici, F., Ferrer, J., Piemonti, L., Marchetti, P., Bugliani, M., Bosco, D., Berishvili, E., Duncanson, P., Watkinson, M., Broichhagen, J., Trauner, D., Rutter, G.A.* and Hodson D.J. Beta cell hubs dictate pancreatic islet responses to glucose. Cell Metabolism 24(3):389-401 pii: S 1550-4131(16)30306-0. doi: 10.1016/j.cmet.2016.06.020. (2016). * Co-corresponding author
  10. Mehta, Z.B., Fine, N., Pullen, T.J., Cane, M.C., Hu, M., Chabosseau, P., Meur, G., Velayos, A., Monaco, A.P., Marselli, L., Marchetti, P. and Rutter G.A. The type 2 diabetes-associated gene VPS13C is required in the murine pancreatic β-cell for normal glucose tolerance. Am J Physiol Endocrin Metab 311(2):E488-507  (2016)
  11. Solomou, A., Philippe, E., Migrenne-Li, S., Gaitan, J., Lang, J., Mangan, C., Rutter G.A. Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell inhibits glucagon release and responses to hypoglycmeia. Nutr Metab 13:46. doi: 10.1186/s12986-016-0104-z. eCollection 2016 (2016)
  12. Merriman, C, Huang, H., Rutter, G.A. and Fu, Dax. The high risk polymorphic variant of human ZnT8 (SLC30A8) is functionally hyperactive. J Biol Chem 291(53):26950-26957. doi: 10.1074/jbc.M116.764605 (2016)
  13.  
  14.  

Review Articles

  1. Gerber, P. and Rutter, G.A. The role of oxidative stress and hypoxia in pancreatic beta cell dysfunction in diabetes mellitus. Review. Metabolic Syndrome, Antioxidants and Redox Signalling, Alice Carrier, 19 Suppl 1:30-41 (2016) 10.1089/ars.2016.6755
  2. Chabosseau, P and Rutter, G.A. Zinc and Diabetes. Archives of Biochimie and Biophysics: Special Addition: Zinc Signalling. 611:79-85. (2016)
  3. Rutter G.A. “Modelling Type 2 diabetes GWAS candidate gene function in hESCs” Commentary for Cell Stem Cell 19(3):281-2 (2016)
  4. Kanda, N., Buenaventura, T., Correa I.R. Jr, Bosco, D., Rutter, G.A. and Tomas, A. Cooperation between EGFR and GLP-1R in pancreatic β–cell survival during oxidative stress. EMJ Diabetes1 (2016) http://viewer.zmags.com/publication/513d7363#/513d7363/55

Original Articles

  1. Zatyka, M., Bellomo, E.A., Permutt, M.A., G.A. and Barrett, T.G. Wolframin depletion in MIN6 β-cells leads to defective glucose signaling and insulin secretion via altered ATP generation and endoplasmic reticulum calcium homeostasis Hum Mol Gen. 24(3):814-27 (2015)
  2. Duca, F.A., Coete, C.D., Rasmussen, B.A., Zadeh-Tahmasebi, M., Rutter, G.A., Filippi, B.M and Lam, T.K.L. Metformin activates duodenal AMPK and a neuronal network to lower glucose production. Nat Med. 21(5):506-11 (2015)
  3. Stasiuk, G.J., Minuzzi, F., Sae-Heng, M., Rivas, C., Jureschke, H-P, Piemonti, L., Allegrini, P., Laurent, D., Duckworth, A.R., Beeby, A. Rutter G.A.* and Long, N.J.*. Dual modal MR/fluorescent ratiometric zinc sensors for pancreatic beta cell imaging. Chem Eu J. 21(13):5023-33 (2015) *Co-corresponding author
  4. Sun, G., da Silva Xavier, G., Gorman, T., Priest, C., Solomou, A., Hodson, D.J., Foretz, M., Viollet, BN., Herrera, P-L., Parker, H., Reimann, F., Gribble, F.M., Migrenne, S., Magnan, C., Marley, A. and Rutter G.A. LKB1 and AMPKa1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia. Mol Metab 4(4):277-286 (2015)
  5. Broichhagen, J.A., Frank, J.A., Johnston, N.R., Mitchell, R.K., Smid, K., Marchetti, P., Bugliani, M., Rutter, G.A., Trauner, D. and Hodson, D.J. A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function. Chem Comm 51 (27):  6018-6021 (2015)
  6. Sellier, M., Pouyet, L., N’Guessan, P., Nollet, M., Capo, F., Peyta, L., Varrault, A., Bertrand, G., Guillaumond, F., Meur, G., Marchetti, P., Dumas, F.F., Bonnafous, Tran, A., Ravier, M., Dalle, S., Gual, P., Muller, D., Rutter, G.A., Servais, S., Iovanna, J.L. and Carrier, A. Defects in mitophagy promote redox-driven metabolic syndrome in the absence of Tumor Protein-53 Induced Nuclear Protein. EMBO Mol Med 7(6):802-18 (2015)
  7. Zhao, L., Oliver, E., Maratou, K., Atanur, S.S., Dubois, O.D., Cotroneo, A., Wang, L., Chabosseau, P.L., Chen, C-N., Ponsa-Cobas, J., Moyon, B., Garcia-Diaz, A.I., Frid, M.G., Webster, Z., Aldashev, A., Ferrer, J., Rutter, G.A., Stenmark, K.R., Aitman, T.J. and Wilkins, M.R. The zinc transporter, ZIP12, regulates the pulmonary vascular response to chronic hypoxia. Nature 524(7565):356-60 (2015)
  8. Martinez-Sanchez, A., Nguyen-Tu, M-S. and Rutter, G.A. DICER inactivation identifies pancreatic β cell « disallowed » genes targeted by microRNAs. Mol Endocrinol 29(7):1067-79 (2015)
  9. Soedling, H., Hodson, D.J., Gribble, F.M., Reimann, F., Trapp, S. and Rutter, G.A. Limited impact on glucose homeostasis of leptin receptor deletion from insulin or proglucagon-expressing cells. Mol Metab. 4, 619-630 (2015)
  10. Hessels, A.M., Chabosseau, P., Bakker, M.H., Wouter, E., Rutter G.A., Taylor, K.M. and Merkx, M. eZinCh-2: a versatile, genetically-encoded FRET senor for cytosolic and intra-organelle Zn2+ ACS Chem Biol 10(9):2126-34 (2015)
  11. Swisa, A., Granot, Z., Tamarina, N., Sayers, S., Bardeesy, N., Philipson, L., Hodson, D.J., Rutter, G.A., Leibowitz, G., Glaser, B., and Dor, Y. Loss of LKB1 in pancreatic beta cells enhances glucose-stimulated insulin secretion despite profound mitochondrial defects. J Biol Chem 290(34):20934-20946 (2015)
  12. Arredouani, A., Parrington. J., Collins, S.C., Ruas, M., Parkesh, R., Clough, F., Pillinger, T., Coltart, G., Rietdorf, K., Royle, A., Jones, E.L., Braun, M., Zhang, Q., Johnson, P.R., Shimomura, K., Morgan, A.J., Lewis, A.M., Chuang, K-T., Tunn, R., Gadea, J., Teboul, L., Bellomo. A., Ashcroft, F.M., Rutter, G.A., Rorsman, P., Churchill, G.C., and Galione, A. NAADP-activation of two-pore channels as a trigger for insulin secretion. J Biol Chem, 290(35):21376-21392 (2015)
  13. Solomou, A., Meur, G., Bellomo, E., Hodson, D.J., Tomas, A., Migrenne Li, S., Philippe, E., Herrera, P., Magnan, C., and Rutter G.A. The zinc transporter Slc30a8/ZnT8 is required in a subpopulation of pancreatic α cells for hypoglycemia-induced glucagon secretion. J Biol Chem 290(35):21432-21442 (2015)
  14. Francis, N., Moore, M., Rutter, G.A. and Burns, C. Changes in microRNA expression during differentiation to definitive endoderm in embryonic and induced pluripotent cells. Gene Expr Patterns 19(1-2):70-82 (2015)
  15. Broichhagen, J., Podewin, T., Meyer-Berg H., Van Ohlen, Y., Johnston, N.R., Jones, B.J., Bloom, S.R., Rutter, G.A., Hoffmann-Roder, A., Hodson, D.J. and Trauner, D. Optical control of the incretin axis using a photoswitchable GLP-1 analogue. Angewante chemie 54(51):15565-15569 (2015)
  16. Akalestou, E., Christakis, I, Solomou, A.M., Minnion, J.S., Rutter, G.A. and Bloom, S.R. Proglucagon-derived peptides do not significantly affect acute exocrine pancreas secretion in vitro and in vivo in the rat. Pancreas, 45(7):967-73 (2015)
  17. Tugay, K., Guay, C., Marques, A.C., Allagnat, F., Locke, F.M., Harries, L.W., Rutter, G.A. and Regazzi, R. Role of microRNAs in age-associated decline of pancreatic beta cell function. Diabetologia 59(1):161-9 (2016)
  18. Mitchell, R.K., Hu, M., Chabosseau, P.L., Cane, M., Meur, G., Bellomo, E.A., Carzaniga, R., Collinson, L.M., Li, W-H., Hodson, D.J and Rutter, G.A. Molecular genetic regulation of Slc30a8/ZnT8 reveals a positive association with glucose tolerance in mice. Mol Endo 30(1):77-91 (2015)
  19. Cane, M.C., Parrington, J., Rorsman, P., Galione, A., Rutter G.A. The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca2+ dynamics and insulin secretion. Cell Calcium, 59(1):32-40 (2015)
  20.  
  21.  

Review Articles

  1. Rutter, G.A. and Chimienti, F. Mutations in SLC30A8 in type 2 diabetes. Diabetologia, 58(1):31-6, 2015
  2. Rutter G.A. and Hodson D.J. Beta cell connectivity in pancreatic islets: a type 2 diabetes target? Cell and Molecular Life Sciences 72(3):453-67 (2015)
  3. G.A., Pullen, T.J., Hodson, D.J. and Martinez-Sanchez, A. Pancreatic β-cell identity, glucose sensing and the control of insulin secretion. Invited Review. Biochem. J. 466 (2), 202-218 (2015)
  4. Rutter G.A. Pancreas micromanages autophagy. Perspective for Science, 347 (6224), 826-827 (2015)
  5. Rutter, G.A., Chabosseau, P., Bellomo, E.A., Maret, W., Mitchell, R.K, Hodson, D.J., Solomou, A., and Hu, M. Intracellular zinc in insulin secretion and action: a determinant of diabetes risk? Proc Nutrition Soc 75(1):61-72 (2016)
  6. Laurent, D., Vinet, L., Lamprianou, S., Daval, M., Filhoulaud, G., Ktorza, A., Wang, H., Sewing, S., Juretschke, H-P., Glombik, H., Meda, P., Boisgard, R., Nguyen, SL, Stasiuk, GJ., Long, N.J., Montet, Z., Hecht, P., Kramer, W., Rutter, G.A.*, and Hecksher-Sorensen, J. Pancreatic β-cell imaging in man: fiction or option? Diabetes, Obesity and Metabolism, 18(1):6-15 (2015) *joint corresponding author

Original Articles

  1. Locke, J, daSilvaXavier, G., Dawe, H.R., Rutter, G.A. and Harries, L.W. Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion. Diabetologia, 57(1):122-128 (2014)
  2. Nita, I.I., Hershfinkel, M., Kantor, C., Rutter, G.A., Lewis, E.C., and Sekler, I. Pancreatic b cell Na+ channels control global Ca2+ signaling and oxidative metabolism by inducing Na+ and Ca2+ responses that are propagated into mitochondria. FASEB J 28(8):3301-12 (2014)
  3. Hodson, D.J., Mitchell, R.K., Marselli, L., Pullen, T.J., Brias, S.G., Semplici, F., Bugliani, M., Marchetti, P., Lavallard, V., Bosco, D., Piemonti, L., Johnson, P.R., Hughes, S.J., Li, D., Li, W-H., Shapiro, A.M.J., Rutter, G.A. ADCY5 couples glucose to insulin release in human islets. Diabetes, 63(9):3009-21. (2014)
  4. Hodson, D.J., Tarasov, A.I., Gimeno-Brias, S., Mitchell, R.K., Johnston, N.R., Haghollahi, S., Cane, M.C., Bugliani, M., Marchetti, P., Bosco, D., Johnson, P.R., Hughes, S.J., and Rutter, G.A. Incretin-modulated beta cell energetics in intact islets of Langerhans. Mol Endo, 28(6):860-71 (2014)
  5. Gerber, P.A., Bellomo, E.A., Meur, G., Hodson, D.J., Solomou, A., Hollinshead, M., Chimienti, F., Lavallard, V.J., Bosco, D., Hughes, S.J., Johnson, P.R. and Rutter, G.A. Hypoxia alters the expression of the type 2 diabetes-associated Zn2+ transporter Slc30a8/ZnT8 and cytosolic Zn2+ levels in human and rodent islets Diabetologia, 57(8):1635-44 (2014)
  6. Pancholi, J, Hodson, D.J., Kobe, K., Rutter, G.A.*, Goldup, S.M.* and Watkinson, M.* Biologically Targeted Probes for Zinc: A Diversity Oriented Modular “Click-SNAR” Approach. Chem Sci. 5(9) 3528-3535 (2014) *Corresponding authors
  7. Mondragon, A., Davidsson, D., Kyriakidou, S., Bertling, A., Cohen, P., Rothery, S., Chabousseau, P., Rutter, G.A. and da Silva Xavier, G. Divergent effects of liraglutide, exendin-4 and sitagliptin on beta-cell mass and indicators of pancreatitis in a mouse model of hyperglycemia. PLoS One, 13;9(8):e104873 (2014)
  8. Chabosseau, P., Tuncay, E., Meur, G., Bellomo, E.A., Hessels, A., Hughes, S., Johnson, P.R.V., Bugliani, M., Marchetti, P., Lyon, A.R., Merkx, M. and Rutter G.A. Mitochondrial and ER-targeted eCALWY probes reveal high levels of free Zn2+. ACS Chem Biol, 9(9):2111-20. (2014)
  9. Kone, M., Pullen, T.J., Sun, G., Ibberson, M., Martinez-Sanchez, A., Sayers, S., Nguyen-Tu, M-S., Kantor, C., Swisa, A., Dor, Y., Gorman, T., Ferrer, J., Thorens, B., Reimann, F., Gribble, F., McGinty, J.A., Chen, L., French, P.M., Birzele, F., Hildebrandt, T., Uphues, I., and Rutter G.A. LKB1 and AMPK differentially regulate pancreatic beta cell identity. FASEB J, 28(11):4972-4985 (2014)
  10. Broichhagen, J., Schonberger, M., Cork, S.C., Trapp, S., Frank, J.A., Marchetti, P., Bugliani, M., Shapiro, A.M.J., Rutter, G.A., Hodson, D.J. and Trauner, D. Optical control of insulin release using a photoswitchable sulfonylurea. Nat Comm 5:5116. (2014)
  11. Zac-Varghese, S., Trapp, S., Richards, P., Sayers, S., Sun, G, Bloom, S.R., Reimann, F., Gribble, F.M. and Rutter G.A. The Peutz-Jeghers kinase LKB1 suppresses polyp formation from proglucagon-expressing entero-endocrine cells. Dis Mod. Mech, 7(11):1275-86 (2014)
  12. Mitchell, R.K., Mondragon, A., Chen, L., McGinty, J.A., French, P.M., Ferrer, J., Thorens, B., Rutter, G.A.*, da Silva Xavier, G.* Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass. Hum Mol Gen. 24(5):1390-1399 (2014) *Co-corresponding author
  13. Piccand, J., Strasser, P., Hodson, D.J., Meunier, A., Ye, T., Keime, C., Birling, C., Rutter, G.A. and Gradwohl, G. Rfx6 maintains the functional identity of adult pancreatic beta cells. Cell Reports, 9(6):2219-32 (2014).
  14.  

Review Articles

  1. Tarasov, A.I. and Rutter, G.A. Use of genetically encoded sensors to monitor cytosolic ATP/ADP ratios in living cells. ED Galluzzi, L, Kroemer, G. Conceptual background of bioenergetics/mitochondrial aspects of oncometabolism. Book Series: Enzymol. 542:289-311 (2014)
  2. Pullen, T.J. and Rutter G.A. Roles of lncRNAs in pancreatic beta cell identity and diabetes susceptibility. Frontiers in Bioscience, 5:193 (2014)
  3. Francis, N., Moore, M., Rutter, G.A. and Burns, C. The role of microRNAs in the pancreatic differentiation of pluripotent stem cells. 3(1), 54-63 (2014)
  4. Rutter G.A. and Pinton P. Mitochondria-associated endoplasmic reticulum membranes in insulin signalling. Diabetes 63 (10) 3163-3165 (2014) (Commentary)
  5. Rutter G.A. Understanding genes identified by genome-wide association studies for Type 2 Diabetes. Diabetic Medicine. 31(12):1480-7 (2014)
  6. Gilon, P., Chae, H-Y., Rutter, G.A. and Ravier, M.A. Calcium signalling in pancreatic β cells in health and in type 2 diabetes. Cell Calcium, 56, 340-361 (2014)

Original Articles

  1. Tarasov A.I., Semplici, F., Li, D., Rizzuto, R., Ravier, M.A., Gilon, P. and Rutter G.A. Frequency dependent mitochondrial Ca2+ accumulation regulates ATP synthesis in pancreatic b-cells. Pflug Arch.- Eur J Physiologie, 465(4):543-54 (2013)
  2. Arensbergen, J., García-Hurtado, J., Maestro, M.A., Tapia, M.C., Rutter, G.A., Vidal, M., and Ferrer, J. Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult beta cells. Genes Dev 27(1):52-63 (2013)
  3. Hodson, D.J., Mitchell, R.K., Bellomo, E.A., Sun, G., Vinet, L., Meda, P., Li, D., Li., W-H., Bugliani, M., Marchetti, P, Bosco, D,.Piemonti, L, Johnson, P.J., Hughes, S.J. and Rutter G.A. Lipotoxicity disrupts human beta cell connectivity. J Clin Invest. 123(10):4182-94 (2013) https://www.jci.org/articles/view/68459
  4. Rivas, C., Stasiuk, G., Gallo, J., Minuzzi, F., Rutter, G.A., Long, N. “Lanthanide (III) Complexes of Rhodamine-DO3A Conjugates as Agents for Dual-Modal Imaging” Authors: Manuscript ID: ic-2013-02233g. Inorganic Chemistry, 52(24):14284-93 (2013)
  5.  
  6.  

Review Articles

  1. Loder, M, Tsuboi, T., Rutter G.A. “Live cell imaging of vesicle trafficking and divalent metal ions by total internal reflection fluorescence (TIRF) microscopy” in Meth Mol Biol 950:13-26 (2013)
  2. Pullen, T.J and Rutter G.A. Could lncRNAs contribute to beta cell identity and its loss in type 2 diabetes? Biochem Soc Trans Jun; 41(3):797-801 (2013)
  3. Rutter, G.A. Cellular and animal models of Type 2 diabetes GWAS gene polymorphisms: what can we learn? Drug Discovery Today: Disease Models 10 (2) e59-e64, (2013). ISSN 17406757
  4. daSilvaXavier, G., Bellomo, E.A., McGinty, J., French, P.M. and Rutter, G.A. Animal Models of GWAS-identified Type 2 Diabetes Genes J Diabetes Res, special Addition “Animal models of diabetes genes and associated complications” Hindawi publishing group. 2013:906590. doi: 10.1155/2013/906590, 2013
  5. Rutter G.A. and Hodson, D.J. Cell-cell communication and insulin secretion from human islets. Endocrinol. 27(12):1984-95 (2013)

Original Articles

  1. Pullen, T.J., Sylow, L, Sun, Halestrap, A.P., Richter, E.A., Rutter, G.A. Over-expression of monocarboxylate transporter-1 (slc16a1) in the pancreatic b cell leads to relative hyperinsulinism during exercise” Diabetes, 61(7):1719-1725 (2012)
  2. da Silva Xavier, G., Mondragon, A., Sun, G., Chen, L., McGinty, J.A., French, P.M. and Rutter, G.A. Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2 null mice. Diabetologia, 55(10):2667-76 (2012)
  3. Tarasov, A.I., Ravier, M.A., Semplici, F., Bellomo, E.A., Pullen, T.J., Gilon, P., Sekler, I., Rizzuto, R. and Rutter, G.A. The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells. PloS One, 7(7): e39722. (2012) doi:10.1371/journal.pone.0039722
  4. Du, X., Ounissi-Benkalha, H., Loder, M.K., Rutter, G.A., Polychronakos, C. Over-expression of ZAC impairs glucose-stimulated insulin translation and secretion in clonal pancreatic β-cells. Diabetes / Metabolism Research and Reviews 28(8):645-53(2012).
  5. Iglesias, J., Barg, S., Vallois, D., Lahiri, S., Roger,C., Yessoufou, A., Pradevand, S., McDonald, A., Bonal, C, Debril, M., Reimann, F., Gribble, G., Metzger, D., Chambon, P., Herrera, P., Rutter, G.A., Prentki, M., Thorens, B., Wahli, W. Modulation of pancreatic β-cell mass and insulin release by PPAR β/a. J Clin Invest, 122(11):4105-17 (2012)
  6.  
  7.  

Review Articles

  1. Leclerc, I., Rutter, G.A., Meur, G and Noordeen, N. Roles of Ca2+ Ions in the Control of ChREBP Nuclear Translocation, J. Endocrinol 213(2):115-22 (2012)
  2. Tarasov, A.I., Griffiths, E.J. and Rutter, G.A. Regulation of ATP production by mitochondrial Ca2+ Cell Calcium 52(1):28-35, 2012
  3. Rutter, G.A. and Pullen, T.J. When less is more: the forbidden fruits of gene repression in the adult beta cell. Diabetes, Obesity and Metabolism 15(6):503-12. (2012)

Original Articles

  1. Leclerc, I., Sun, G., Morris, C., Fernandez-Millan, E., Nyerinda, M., Rutter, G.A. AMP-activated protein kinase regulates glucagon secretion from pancreatic alpha cells. Diabetologia 54(1):125-34 (2011)
  2. Lam CK, Chari, M., Rutter, G.A. and Lam TK. Hypothalamic nutrient sensing activiates forebrain-hindbrain neuronal circuite to regulate glucose production in vivo. Diabetes 60(1):107-13 (2011)
  3. daSilvaXavier, G., Sun, G., Qian, Q, Rutter, G.A. and Leclerc, I. ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells. Biochem Biophys Res Comm 402(2):252-7 (2010)
  4. Sun, G., Reynolds, R., Leclerc, I., and Rutter, G.A. RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis Disease Models and Mechanisms 4(2):193-202 (2011)
  5. daSilvaXavier, G., Farhan, H., Kim, H., Caxaria, S., Johnson, P.R., Hughes, S., Bugliani, M., Marselli, L., Marchetti, P., Birsele, F., Sun, G., Scharfmann, R., Rutter, J., Siniakowicz, K., Weir, G., Parker, H., Reimann, F., Gribble, F.M., and Rutter, G.A. Per-arnt-sim (PAS) domain-containing protein kinase is down-regulated in human ilsets in type 2 diabetes and regulates glucagon secretion. Diabetologia 54(4):819-27  (2011)
  6. Dominguez,V., Raimondi, C., Somanath, S., Bugliani, M., Loder, M.K., Edling, C.E., Divecha, N., da Silva Xavier, G., Marsella, L., Persaud, S.J., Turner, M.D, Rutter, G.A. Marchetti, P., Falasca, M., and Maffucci, T. Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells. J Biol. Chem 286(6):4216-25 (2011)
  7. Meur,, Qian,Q, Da Silva Xavier, G., Pullen, T.J., Tsuboi,T., McKinnon, C.M., Fletcher, L.M., Tavaré, J.M., Hughes, S., Johnson, P., Rutter G.A. Nuclear-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6). J Biol. Chem 286 (15): 13647-13656 (2011)
  8. Bellomo, E.A., Meur, G, and Rutter, G.A. Glucose regulates free cytosolic Zn2+ concentration, Slc39 (ZiP) and metallothionein gene expression in primary pancreatic islet β-cells J Biol Chem 286(29):25778-89 (2011)
  9. Pullen, T.J., daSilvaXavier, G., Kelsey, G., Rutter,G.A. MiR-29a, and -29b contribute to pancreatic β-cell specific silencing of monocarboxylate transporter 1(Mct1/slc16a1). Mol Cell Biol 31 (15)  3182-3194 (2011)
  10. Locke, J.M., da Silva Xavier, G., Rutter, G.A.*, and Harries, L.W. An alternative polyadenylation in TCF7L2 generates isoforms which inhibit TCF-LEF-dependent target genes. Diabetologia, 54(12):3078-82 (2011) *Co-corresponding author
  11. Semplici, F., Vaxillaire, M., Fogarty, S., Semach, M., Bonnefond, A., Fontes, G., Philippe, J., Meur, G., Diraison, F., Sessions, R.B., Rutter, J., Poitout, V., Froguel, P, and Rutter, G.A. A human mutation within the per-ARNT-sim (Pas) domain-containing protein kinase (PASK) causes basal insulin hypersecretion. J Biol Chem 286(51):44005-14 (2011)
  12. Li, D., Chen, S., Bellomo, E.A., Tarasov, A.I., Kaut, C., Rutter, G.A. and Li, W.H. Imaging dynamic insulin release using a fluorescent zinc probe, ZIMIR. Proc Natl Acad Sci, 108(52):21063-8 (2011)
  13. Noordeen, N.A., Meur, G., Rutter, G.A.* and Leclerc, I. Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca2+ ions in pancreatic b Diabetes 61(3):574-85 (2011) *Co-corresponding author
  14.  
  15.  

Review Articles

  1. Sun, G., Rutter, G.A. Targeting the AMP-regulated kinase (AMPK) family to treat diabetes: a research update. Diabetes Management 1 (3):333-347 (2011)

Original Articles

  1. Noordeen, N, Khera, TK, Sun, G., Longbottom, E.R., da Silva Xavier, G., Rutter, G.A., Leclerc, I. ChREBP is a negative regulator of ARNT/HIF-1β gene expression in pancreatic islet β-cells. Diabetes, 59(1):153-60 [IF= 8.398] (2010)
  2. Pullen, T.J., Khan, AM., Barton, G., Sun., G., and Rutter, G.A. Identification of genes selectively disallowed in the pancreatic islet. Islets, 2(2), 89-95 (2010)
  3. Sun, G., Tarasov, A.I., McGinty, J., McDonald, A., daSilvaXavier, G., Gorman, T., Marley, A., French, P.M., Parker, H., Gribble, F., Reimann, F., Viollet, B., Leclerc, I., Rutter, G.A. Ablation of AMPKα1 and α2 from pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo. Diabetologia, 53(5) 924-936 (2010)
  4. Voronina, S.G., Barrow, S.L., Simpson, A.W., Gerasimenko, O.V., da Silva Xavier, G., Rutter, G.A. Petersen, O.H., and Tepikin, A.V. Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells. Gastroenterology 138(5):1976-87 (2010)
  5. Wijesekara, N., Dai, F.F., Hardy, A.B., Giglou, P.R., Bhattacharjee, A., Koshkin, V., Chimienti, F., Gaisano, H.Y., Rutter, G.A. and Wheeler, M.B. Beta cell specific ZnT8 deletion in mice causes marked defects in insulin processing, crystallization and secretion. Diabetologia, 53(8):1656-1668 (2010)
  6. Sun, G., Tarasov, A.I., McGinty, J.A., French, P.M., McDonald, A., Leclerc, I., and Rutter, G.A. LKB1 deletion from insulin-expressing cells diminishes food intake and modifies pancreatic β-cell morphology to enhance insulin secretion in vivo. Am J Physiol, 298(6):E1261-73 (2010)
  7. MBaya, E., Oules, B., Caspersen, C., Tacine, R., Munnich, A., Rotig, A., Rizzuto, R., Rutter, G.A., Paterlini-Brechot, P., and Chami, M. Regulation of calcium signaling-dependent bioenergetics in mitochondrial respiratory chain complex II deficiency. Cell Death Diff. 17(12):1855-66 (2010)
  8. An, R, da Silva Xavier,, G, Semplici, S, Vakhshouri, S, Hao,, H-X, Rutter, J, Pagano, M.A., Meggio, F, Pinna, A., and Rutter, G.A. Pancreatic and Duodenal Homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization Biochemicaland Biophysical Research Communications. 399(2):155-61 (2010)
  9. Yang,C.S., Lam, C.K.L., Chari, M., Cheung, G.W.C., Kokorovic, A.K., Sun, G., Leclerc, I., Rutter, G.A., Lam, T.K. Hypothalamic AMPK regulates glucose production. Diabetes  59(10):2435-2443 (2010)
  10.  
  11.  

Review Articles

  1. McDonald, A, Fogarty, S, Leclerc, I., Hill, E.V., Hardie, D.G., Rutter, G.A. Cell wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphprylation at Ser517/520 in glucose-stimulated insulin granule movement. Biochem Soc Trans. 38(Pt 1):205-8 (2010)
  2. Rutter, G.A. Think zinc: new roles for zinc in the control of insulin secretion (Addenda). Islets, 2:1,1-2 (2010)
  3. Loder, M.K., Bellomo, E.A., Tarasov, A.I., Meur, G., Rutter, G.A. Imaging signal transduction in the β-cell: from organelle to organism. In Treatment Strategies : Diabetes (2010). pp. 31 – 28. Edited by The Cambridge Research Centre, London and published in line with the EASD Congress, Stockholm, Sweden 20 – 24 Sep 2010. http://viewer.zmags.com/publication/ad06b13c#/ad06b13c/30

Original Articles

  1. da Silva Xavier, G., Loder, M., McDonald, A. Carzaniga, R, Kronenberger, K, Barg, S. and Rutter G.A. TCF7L2 regulates late events in insulin secretion from pancreatic islet β-cells. Diabetes 58(4):894-905 (2009) [see also Commentary by Braun, Rorsman and Gloyn]
  2. Nicolson, T.J. Bellomo, E.A., Wijesekara, N., Loder, M.K., Baldwin, J.M., Gyulkhandanyan, A.V., Koshkin, V., Tarasov, A.I., Carzaniga, R., Kronenberger, K., Taneja, T.K., da Silva Xavier, G., Libert, S., Froguel, P., Scharfmann, R., Stetsyuk, V., Ravassard, P., Parker, H., Gribble, F.M., Reimann, F., Sladek, R., Hughes, S.J., Johnson, P.R.V., Masseboeuf, M., Burcelin, R., Baldwin, S.A., Liu, M., Lara-Lemus, R., Arvan, P., Schuit, F.C., Wheeler, M.B., Chimienti, F., Rutter, G.A. Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants Diabetes, 58(9):2070-83 (2009) https://diabetesjournals.org/diabetes/article/58/9/2070/24626/Insulin-Storage-and-Glucose-Homeostasis-in-Mice 
  3. Lerner, R.G., Depatie, C., Rutter G.A., Screaton, R. Balthasar, N. A role for the CREB coactivator TORC2 in the hypothalamic mehanisms linking glucose-sensing with gene regulation. EMBO Rep [IF=7.099] 10(10):1175-81 (2009)
  4. Vinkenborg, J.L., Nicolson, T.J., Bellomo, E.A., Koay, M.S., Rutter, G.A.* Merkx, M. Genetically encoded FRET sensors to monitor Zn2+ Nat Methods 6(10):737-40 (2009) *Corresponding author
  5. McDonald, A, Fogarty, S., Leclerc, I, Hill, E., Hardie, D.G. and Rutter, G.A. Control of insulin granule dynamics by AMPK-dependent KLC1 phosphorylation. Islets, 1(3), 1-11 (2009).
  6. Lemaire, K., Ravier, M.A., Schaenen, A., Creemers, J.W.M., Van de Plas, R., Granvik, M., Waelkens, E., Chimienti, F., Rutter, G.A., Gilon, P., in’t Veld, P., Schuit. Insulin crystallisation depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice. Proc Natl. Acad. Sci. 106  (35): 14872-14877 [IF= 9.38] (2009)
  7. Vinkenborg, J.L., Bellomo, E.A., Nicolson, T.J., Koay, M.S., Merkx, M., Rutter, G.A. Accurate measurement of cytosolic freezinc concentration using eCALWY variants: a toolbox of genetically encoded FRET sensors. Nat Protocols doi: 1038/nprot.2009.168 (2009) http://www.natureprotocols.com/2009/09/22/accurate_measurement_of_cytoso.php
  8. Meur, G., Simon, A., Harun, N., Dechaume, A., Bonneford, A., Virally, M., Fetita, S., Tarasov, A.I., Boesgaard, T.W., Pedersen, O., Hansen, T., Polak, M., Gautier, J-F, Froguel, P., Rutter, G.A.*, Vaxillaire, M. Insulin gene mutations resulting in a MODY phenotype: marked differences in Clinique presentation, metabolic status and pathogenic effect through ER retention. Diabetes, 59(3):653-61 [IF= 8.398] (2009) * corresponding author
  9.  
  10.  

Review Articles

  1. Rutter, G.A. and Leclerc I. “The AMP-regulated kinase family: enigmatic targets for diabetes therapy” in “Endocrine Aspects of Type II Diabetes”, special Edition of Mol Cell Endocrinol, 297(1-2):41-49 (2009). Elsevier Press, Ed, A. Sjoholm
  2. Rutter G.A. Regulating glucagon secretion: somatostatin in the spotlight. Commentary. Diabetes 58(2):299-301 (2009)

Original Articles

  1. Zatyka M, Ricketts, C, da Silva Xavier, G., Minton, JA, Fenton, S, Hofmann-Thiel, S, Rutter G.A., and Barrett  Sodium-potassium ATPase beta 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum (ER) protein involved in ER stress, Hum Mol Genet 17(2):190-200 (2008)
  2. Barrow, SL, Voronina, S., da Silva Xavier, G., Chvanov, M., Petersen, O.H, Gerasimenko, O, Rutter, G.A., Tepikin, A. ATP depletion synchronously inhibits store-dependent calcium influx, calcium extrusion and calcium release from internal stores but not bile-induced calcium responses. Implications for acute pancreatitis. Pflug Arch, European Journal of Physiol 455(6):1025-39 (2008)
  3. Chavey, A., Diraison, F., Siew, L.K., Wong, F.S., and Rutter G.A. Inhibition of AMP-activated protein kinase protects pancreatic b-cells from cytokine-mediated apoptosis and CD8+ T-cell induced cytotoxocity. Diabetes 57(2):415-23. (2008)
  4. Diraison, F., Ravier, M.A., Richards, S.K., Smith, R.M., Shimano, H. and Rutter G.A. SREBP1 is required for the induction by glucose of pancreatic β-cell genes involved in glucose sensing. J Lipid Res 49(4):814-22 (2008)
  5. Tarasov, A.I., Nicolson, T., Riveline, J-P, Taneja, T.K., Baldwin, S.A., Baldwin, J., Charpentier, G., Gautier, J-F, Froguel, P, Vaxillaire, M, Rutter, G.A. A rare mutation in ABCC8/SUR1 leading to altered KATP channel activity and β-cell glucose sensing is associated with type 2 diabetes mellitus in adults. Diabetes 57(6):1595-604 (2008)
  6. Cunha, D.A., Hekerman, P, Ladriere, L., Bazarra-Castro, A., Ortis, F., Wakeham, M.C., Moore, F., Rasschaert, J., Cardozo, A.K., Bellomo, E., Overburgh, L., Mathieu, C., Lupi, R., Hai, T., Herchuelz, A., Marchetti, P., Rutter, G.A., Eizirik, D.L, Cnop, M. Initiation and execution of lipotoxic ER stress in pancreatic beta cells. J Cell Sci 121(14):2308-2318 (2008).
  7.  

Review Articles

  1. Rutter, G.A., and Wong, F.S. The Pancreatic β-Cell: Birth, Life and Death. Bichem Soc Trans 36 (Pt 3):267-71 (2008)
  2. Loder, M.K., da Silva Xavier, G.e, McDonald, A., Rutter, G.A. TCF7L2 controls insulin gene expression and insulin secretion in mature beta-cells. Bichem Soc Trans 36(Pt 3):357-9 (2008)
  3. Rutter, G.A., Bellomo, E.A. e Ca2+ signalling: a new route to NAADP. Commentary for Biochem J 411(1):e1-e3 (2008)
  4. Ravier, M.A. e, Tsuboi, T.e, Rutter, G.A. Imaging a target of Ca2+ signalling: dense core granule exocytosis viewed by total internal reflection of fluorescence microscopy, in “Optical
    Methods in Calcium Signaling” (Elsevier ; Thomas, A.P. Ed) Methods, 46(3):233-8 (2008)
  5. Griffiths, E.J. and Rutter, G.A. Mitochondrial calcium as a key regulator of mitochondrial ATP production. For Biophys. Act 1787(11):1324-33 (2008)

Original Articles

  1. McKinnon, C.M., Ravier, M.A. and Rutter, G.A. FoxO1 is required for preproglucagon gene expression and regulated glucagon release from pancreatic a- (TC1-9) cells. J Biol Chem 281(51):39358-69 (2006)
  2. Mountjoy, P.D., Bailey, S.J. and Rutter G.A. Glucose and leptin silence neuropeptide Y-expressing hypothalamic neurons by inhibiting AMP-activated protein kinase. Diabetologia 50(1):168-77 (2007)
  3. Bailey, S.J. Ravier, M.A., Rutter, G.A. Glucose-dependent regulation of GABA-A receptor expression in mouse pancreatic b-cells. Diabetes 56(2):320-7 (2007)
  4. Guillemain, G., Filhouland, G., da Silva Xavier, G., Rutter, G.A., Scharfmann, R. Glucose is necessary for embryonic endocrine cell differentiation. J Biol Chem. 282(20):15228-37 (2007)
  5. Baroukh, N, Ravier, M.A., Loder, M.A., Hill, A.V., Bounacer, A., Scharfmann, R., Rutter, G.A., Van Obberghen E. MicroRNA-124a2 regulates foxa2 expression and intracellular signaling in pancreatic b-cell lines. J Biol Chem 282(27):19575-88 (2007)
  6. Otonkoski, T., Jiao, H., Kaminen-Ahola, N., Tapia-Paez, I., Ullah, M.S., Parton, L.E., Schuit , F., Quintens, R., Sipilä, I., Mayatepek, E., Meissner, T., Halestrap, A.P., Rutter A. and Kere, J.  Physical exercise-induced hyperinsulinemic hypoglycemia caused by failure of monocarboxylate transport 1 silencing in pancreatic beta cells. Am J Hum Genet 81(3):467-474 (2007)
  7. Jacquet, , Zarrinpashneh, E., Chavey, A., Leclerc, I., Cohen, P, Rutter,G.A., Bertrand, L., Marber, M.S.  The relationship between p38 mitogen-activated protein kinase and AMP-activated protein kinase during myocardial ischemia. Cardiovas Res. 76(3):465-72 (2007)
  8.  

Review Articles

  1. Bell, C.J. , Manfredi, G, Griffiths, E.J., and Rutter, G.A. Luciferase Expression and Imaging: Application to Cardiac Myocytes, in “Mitochondria”, Vol 2 Cell Biol., (Eds, Pon, L.A. and Schon, E.A.) 80:341-52 (2007)
  2.  

Original Articles

  1. Storto, M., Capbianco, L., Battaglia, G., Molinaro, G, Gradini, R., Riozzi, B., Mitchell, K.J. d, Bruno, V., Vairetti, M.P., Rutter, G.A., and Nicoletti, F. Insulin secretion is under the control of Type-5 metabotropic glutamate receptors Mol Pharmacol 69(4):1234-41, 2006
  2. Tsuboi, T, Ravier, M.A., Parton, L.E. and Rutter, G.A. Sustained exposure to elevated glucose concentrations modifies glucose signaling and the mechanics of secretory vesicle fusion in primary rat pancreatic b-cells. Diabetes 55(4):1057-1065, (2006)
  3. Varadi, A., Grant, A, McCormack, M, Nicholson, T. , Magistri, M, Kathryn J. Mitchell, K.J., Halestrap A.P., Yuan, H, Schwappach, B, and  Rutter, G.A. Intracellular ATP-sensitive K+ channels in mouse b-cells: against a role in organelle cation homeostasis.  Diabetologia 49(7):1567-77 (2006);
  4. Parton, L., McMillen, PJ, Shen, Y, Docherty, E, Sharpe, E, Diraison, F., Briscoe, CP, Rutter GA. Role of SREBP-1c in defective insulin secretion from Zucker diabetic fatty rats: functional and gene profiling analysis. Am J. Physiol. 291(5):E982-94 (2006)
  5. Motakis, E.S., Nason, G.P., Fryzlewicz, P. and Rutter, G.A. Variance stabilization and normalization for one colour microarray data using a data-driven multiscale approach. Bioinformatics 22(20):2547-53 (2006)
  6. Bell, C.J., Bright, NA, Rutter, G.A., Griffiths, E.J. ATP regulation in adult cardiomyocytes: time resolved decoding of rapid mitochondrial calcium spiking imaged with targeted photoproteins. J Biol Chem 281(38):28058-67 (2006)
  7. Rencuerel, F, Kaufmann, M, Stroka, D, Foretz, M, Viollet, B, Leclerc, I., da Silva Xavier, G., Rutter, G.A., Meyer, UA Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver. Mol Pharmacol 70(6):1925-34 (2006)
  8. da Silva Xavier, G., Rutter, G.A. [joint first authors] Diraison, F., Andreolas, C., and Leclerc, I. f Carbohydrate-response element binding protein (ChREBP) binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic MIN6 b-cells J Lipid Res. 47(11):2482-91 (2006)
  9.  

Review Articles

  1. Rutter, G.A. Varadi, A. e, Tsuboi, T. e, Parton, L.E. e, Ravier, M. Insulin secretion in health and disease : genomics, proteomics and single vesicle dynamics Biochem Soc Trans 34 (2), 247-250 (2006)
  2. An, R da Silva Xavier, G, Hao, HX, Semplici, F, Rutter, J, Rutter, GA. Regulation by Per-Arnt-Sim (PAS) kinase of pancreatic duodenal homeobox-1 nuclear import in pancreatic beta-cells. Biochem Soc Trans. 34 (Pt 5):791-3 (2006).
  3. Rutter, G.A. Tsuboi, T.e, Ravier, M.A. e Ca2+ microdomains and the control of insulin secretion. Cell Calcium, 40(5-6):539-51. (2006)
  4. Rutter, G.A. Moving Ca2+ from the ER to mitochondria: is spatial intimacy enough? Biochem Soc Trans 34(Pt 3):351-5, 2006
  5. Rutter, G.A and Hill, E.V. Insulin secretion: walk, kiss, pause..then run. Physiologie 21:189-96 (2006)
  6. Mountjoy, P.D. and G.A. Glucose sensing by hypothalamic neurons and pancreatic islet cells: AMPle evidence for common mechanisms? Experimental Physiologie 92(2):311-9 (2006)
  7. Kola, B, Boscaro, M, Rutter, G.A, Ashley B. Grossman, A.B., Korbonits,M Expanding role of AMPK in Endocrinology in (2006) Trends Endocrinology and Metabolism, 17(5):205-15 (2006)
  8. Rutter, G.A., Loder, M.K. and Ravier, M.A.e Rapid 3D imaging of individual insulin release events by Nipkow disc confocal microscopy Biochem Soc Trans 34(Pt 5):675-8 (2006)
  9. Rutter, G.A. Mécanises moléculaire de la sécrétion d’insuline. Médecine clinique and endocrinolgie diabète, Hors-Serie,  pp 9-14, (2006)

Original Articles

  1. Gallo, A, Giulio, C, Pinton P, Elisabetta,I, Ellen, M, Rutter G.A., Rizzuto R., Semplicini, A., Avogaro, A, Metformin Prevents Glucose-Induced PKCbeta2 Activation In Human Umbilical Vein  Endothelial Cells Through an Antioxidant Mechanism. Diabetes 54(4):1123-31, 2005
  2. Varadi, A., Tsuboi, T., Rutter, G.A. Myosin Va transports dense core vesicles in pancreatic MIN6 b-cells. Mol Biol Cell 16(6):2670-2680, 2005 
  3. Ravier, M.A. and Rutter G.A. Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic a-cells. Diabetes 54, 1789-1797, 2005
  4. Tsuboi, T., Ravier, M.A., Xie, H., Ewart, M-A, Gould, G.W., Baldwin, S.A., Rutter, G.A. The mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis. Biol. Chem. 280 (27) 25565-25570, 2005
  5. Richards, S.K., Parton, L.E., Leclerc, I., Rutter, G.A., Smith, R.M. Over-expression of AMP-activated protein kinase impairs pancreatic b-cell function in vivo. J Endocrinol 187, 225-235 (2005)
  6.  

Review Articles

  1. Rutter G.A. The b-cell at work: Visualising insulin secretion in living cells. The Biochemist (Portland Press) 27 (5)9-12, (2005)

Original Articles

  1. da Silva Xavier, G., Qian, Q., Cullen, P.J. and Rutter, G.A. Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing. Biochem J. (2004); 377(Pt 1):149-58 [Biochem J. “Hot” paper – see commentary by P. Shepherd, Jan 1;377(Pt 1):e1-2]
  2. Mitchell, K.J., Tsuboi, T., Rutter, G.A. “Role for plasma membrane-related Ca2+-ATPase-1 (PMR1 / ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing” Diabetes 53(2), 393-400 (2004).
  3. Tsuboi, T., Lippiat, J.D., Ashcroft, F.M. and Rutter G.A. ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transfer Proc Natl Acad. Sci 101, 76-81 (2004)
  4. Guillemain, G., da Silva Xavier, G., Rafiq, I., Leturque, A., and Rutter, G.A. Importin b mediates the glucose-stimulated nuclear import of pancreatic and duodenal homeobox-1 in pancreatic islet b-cells (MIN6) Biochem J 378, 219-227 (2004)
  5. Diraison, F., Parton, L., Ferré P., Foufelle F., Briscoe C., Leclerc, I., and Rutter, A. Over-expression of sterol regulatory element binding protein-1c (SREBP-1c) induces lipogenesis and decreases glucose-stimulated insulin release from rat pancreatic islets; reversal by activation of 5’AMP-activated protein kinase. Biochem J 373(3), 769-778 (2004)
  6. Leclerc, I., da Silva Xavier, G., Rutter, G.A. AMP-activated protein kinase: a new b-cell glucose sensor? Regulation by amino acids and calcium ions. Diabetes 53, S3, S67-S74 (2004)
  7. Diraison, F., Leclerc, I., Motakis. , Parton, L., and Rutter G.A. Impact of sterol response element binding protein-1c and AMP-activated protein kinase on pancreatic islet b-cell gene expression profile. Diabetes 53, S3, S84-S91 (2004)  
  8. Leclerc, I., Woltersdorf, W.W., da Silva Xavier, G., Rowe, R.L., Cross, S.E., Korbutt, G.S., Rajotte, R.V., Smith, R. and Rutter, G.A. Metformin, but not leptin, regulates 5’AMP-activated protein kinase activity in pancreatic islets: impact on glucose-stimulated insulin secretion. Am J Physiol 286(6):E1023-31. (2004)
  9. Walker,S.A., Kupzig,S., Wheeler,L.C., Tsuboi,T., Lockyer,P.J., Bivona,T., Cozier,G.E., Buckler,A., Rutter, G.A., Allen,M., Philips,M.R., Cullen, P.J. Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca(2+) oscillations. EMBO J, 23(8):1749-60, 2004
  10. Ma, D., Shield, J.P.H., Dean, D., Leclerc, I., Rutter, G.A. and Kelsey, G. Defective glucose homeostasis in transgenic mice over-expressing the human transient neonatal diabetes mellitus (TNDM) locus. J Clin Invest 114 (3) 339-348 (2004)
  11. da Silva Xavier, G., Rutter, J., and Rutter G.A. Involvement of PAS kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox-1 gene expression by glucose. Proc Natl Acad Sci 101(22), 8319-8324 (2004)
  12. Parton, L., Diraison, F., Neill, S.E., Ghosh, S.J., Rubino, M.A., Bisi, J.F., Briscoe, C.P., Rutter G.A. Impact of PPARg activation on pancreatic islet gene expression profile analysed with oligonucleotide micorarrays. Am J. Physiol. 287(3):E390-404, 2004
  13. Varadi, A., Johnson-Cadwell, L.I., Cirulli, V.,Yoon,, Allan, V.J,, and Rutter, G.A. Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1. J Cell Science 117 (Pt 19):4389-400, 2004
  14. Varadi, A., Cirulli, V., and Rutter, G.A. Mitochondrial localization as a determinant of capacitative Ca2+ entry in HeLa cells. Cell Calcium 36(6):499-508, 2004
  15. Varadi, A., Rutter, G.A. Ca2+-induced Ca2+ release in clonal pancreatic b-cells: examination of the use of ER-targeted “Cameleons” Endocrinology 145(10):4540-9. 2004
  16. Reimann, F., Williams, L., da Silva Xavier, G., Rutter, G.A., Gribble, F.M. Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells. Diabetologia 47(9):1592-601, 2004
  17. Ivarsson, R., Obermüller, S., Rutter, G.A.., Galvanovskis, J., and Renström, E. Temperature-sensitive random insulin granule diffusion is a prerequisite for the recruitment of insulin granules for release. Traffic 5: 1-13, 2004
  18. Visch H., Rutter, G.A., Koopman W.J.H., Varadi A., Mitchell K.J., van den Heuvel L.P., Smeitink J.A.M. and Willems P.H.G.M. Inhibition of mitochondrial Na+-Ca2+ exchange restores agonist-induced ATP and Ca2+ homeostasis in human complex I deficiency. J Biol Chem 279(39):40328-36, 2004
  19. Tsuboi, T., McMahon, H, and Rutter G.A. Mechanisms of dense core vesicle recapture following “kiss and run” (“cavicapture”) exocytosis in insulin secreting cells. J Biol Chem 279(45):47115-24, 2004
  20.  

Review Articles

  1. Rutter, G.A., Tsuboi, T. e, Kiss and Run of Dense Core Secretory Vesicles. Neuroreport 19 (1) 79-81 (2004)
  2. Rutter, G.A., da Silva Xavier, G, Tsuboi, T. e, Mitchell, K.J. d and Hanrahan, J.W. Probing cellular function with bioluminescence imaging in Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics, Wiley & Sons, Tavaré, J.M. and Dunn, M, eds (2004) Vol 5 pp 2111-2121
  3. Rutter G.A. Visualising insulin secretion (European Association for the Study of Diabetes, 39 th Minkowski Award Lecture) Diabetologia 47(11):1861-72 (2004)

Original Articles

  1. Tsuboi, T., da Silva Xavier, G., Holz, G.G., Jouaville, L.S. Thomas, A.P. and Rutter, G.A. Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 b-cells. Biochem J. (2003) 369 (2) 287-299
  2. Mitchell, K.J., Lai, F.A. and Rutter, G.A. Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate (NAADP) receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic b-cells (MIN6) Biol. Chem. (2003) 278(13):11057-
  3. Tsuboi, T., and Rutter, G.A. Multiple forms of kiss and run exocytosis revealed by evanescent wave microscopy Biol. (2003) 13(7):563-7
  4. da Silva Xavier, G., Leclerc, I., Tsuboi, T., and Rutter, G.A. Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. J. (2003) 371(Pt 3):761-74
  5. Eto, K., Yamashita, T., Hirose, K., Tsubamoto, Y., Ainscow, E.K., Rutter, G.A., Noda, M., Kimura, S. Iino, M.and Kadowaki, T. Glucose Metabolism and Glutamate Analogue Acutely Alkalinize Insulin Secretory Vesicles of Pancreatic b Cells, Am J. Physiol. (2003) 285, E262-71
  6. Varadi, A., Tsuboi, T., Johnson-Cadwell, L.I., Allan, V.J. Rutter, G.A. Kinesin I and cytoplasmic dynein orchestrate glucose-stimulated insulin-containing vesicle movements in clonal MIN6 b-cells. Biophys.Res. Comm. (2003) 311, 272-282.
  7. Tsuboi, T., da Silva Xavier, G., Leclerc, I., and Rutter, G.A. 5′ AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics Biol. Chem. 278(52):52042-52051, 2003
  8.  

Review Articles

  1. Rutter, G.A. and Leclerc, I.f Roles of 5’AMP-activated protein kinase in mammalian glucose homeostasis. Biochem J. Invited Review 375 (1) 1- 16(2003)
  2. Rutter G.A. Insulin secretion: Fatty acid signaling via serpentine receptors Curr Biol. Dispatch 13(10):R403-5. (2003)
  3. Rutter, G.A. Calcium signalling: NAADP comes out of the shadows. Commentary for Biochem. J. 373(Pt 2):1-2 (2003)
  4.  

Original Articles

  1. Andreolas, C., da Silva Xavier, G., Diraison, F., Zhou, C., Varadi, A., Lopez-Casillas, F., Ferré, P, Foufelle, F., Rutter, G.A. Stimulation of acetyl-CoA carboxylase (ACC1) transcription by glucose requires insulin release and sterol regulatory element binding protein (SREBP1c) function in pancreatic MIN6 b-cells. 51, 2536-2545 (2002)
  2. Ainscow, E.K., Rutter, G.A. Glucose-stimulated oscillations in free cytosolic ATP concentration imaged in single islet b-cells: evidence for a Ca2+ dependent mechanism Diabetes 51, Suppl 1:S162-S170 (2002)
  3. Varadi, A. & Rutter G.A. Dynamic imaging of endoplasmic reticulum [Ca2+] in MIN6 b-cells using recombinant cameleons: roles of SERCA2 and ryanodine receptors Diabetes 51, Suppl 1:S190-S201 (2002)
  4. Palmer, G. Rutter, G.A. and Tavaré, J., Insulin stimulated fatty acid synthase gene expression does not require increased sterol-response-element-binding protein-1 transcription in primary adipocytes, Biochem Biophys Res Comm (2002) 291(3):439-443.
  5. Nicholls, L.I. and Ainscow, E.K. and Rutter G.A. Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase (PDH): impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets. Biochem Biophys Res Comm. (2002) 291(4):1081-8
  6. Ainscow, E.K., Mirshamsi, S., Tang, T., Ashford, M.L., and Rutter, G.A. Dynamic imaging of free cytosolic ATP concentration during fuel sensing by hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K+ channels, Physiol, 544.2, 429-445 (2002).
  7. Pinton, P. Tsuboi, T. Ainscow, E.K., Pozzan, T., Rizzuto, R. and Rutter, G.A. Dynamics of glucose-induced membrane recruitment of protein kinase C bII in living pancreatic islet b-cells. Biol. Chem., 277(40):37702-10. (2002)
  8. Varadi, A., Ainscow, E.K., Allan, V.J. & Rutter G.A. Involvement of conventional kinesin in glucose-stimulated secretory-granule movements and exocytosis in clonal pancreatic b-cells. Cell Sci., 115 (21): 4177-89 (2002)
  9.  

Review Articles

  1. Leclerc, I. Viollet, B. da Silva Xavier, G. Kahn, A. and Rutter, G.A. Role of AMP-activated protein kinase in the regulation of gene transcription. Biochem Soc Trans, 30:307-311 (2002)
  2. Varadi, A. Ainscow, E.K Attan, V. J. and Rutter G.A. Molecular mechanisms involved in secretory vesicle recruitment to the plasma membrane in β-cells. Biochem Soc Trans, 30:328-332 (2002)
  3. Leclerc, I. da Silva Xavier, and Rutter, G.A. AMP-activated protein kinase: a key regulator of gene transcription in mammalian cells. Progress in Nucleic Acid Research and Biologie Moléculaire 71: 69 – 90 (2002)
  4. Leclerc, I. , Doiron, B, Vaulant, S, and Rutter G.A. AMP-activated protein kinase and the regulation of gene expression Biochem SocTrans 30(2), 307 – 11(2002)
  5. Varadi, A. , and Rutter, G.A. Regulation of secretory vesicle movement in insulin secreting cells Biochem Soc Trans 30(2), 328 – 32(2002)
  6.  

Original Articles

  1. Zhao C., Wilson, C.M., Schuit, F., Halestrap, A.P. and Rutter, G.A. Expression and distribution of lactate / monocarboxylate transporter (MCT) isoforms in pancreatic islets and the exocrine pancreas 50, 361-366 (2001).
  2. Ainscow E.K., Rutter G.A. Mitochondrial priming modifies Ca2+ oscillations and insulin secretion in pancreatic islets Biochem J. [IF=4.326] 353:175-80 (2001).
  3. Mitchell, K.J., Pinton, P., Varadi, A., Ainscow, E.K., Pozzan, T., Rizzuto, , and Rutter, G.A. Dense core secretory vesicles revealed as a dynamic Ca2+ store in neuroendocrine cells with a VAMP2.aequorin chimaera J. Cell Biol. 155, 41-51 (2001)
  4.  

Review Articles

  1. Porcelli, A.M., Pinton, P., Ainscow, E.K., Chiesa, A.,Rugolo, M. Rutter, G.A. Rizzuto, R. Targeting of Reporter Molecules to Mitochondria to measure Calcium, pH and ATP in “Mitochondria”, Cell Biol., 65 (Eds, Pon, L.A. and Schon, E.A.) 2001;65:353-80 (2001)
  2. Rutter, G.A. “Nutrient-secretion coupling in the pancreatic islet b-cell: Recent advances” Molecular Aspects of Medicine (Elsevier), 22(6):247-84 (2001)
  3. Delzenne, N, Ferré, P. Beylot, M., Daubioul, C., Declercq, B., Diraison F. , Dugail, I., Foufelle, F., Foretz, M., Laville, M., Mace, K., Reimer, R., Palmer, G. e, Rutter, G.A. c, Tavare, J.M., Van Loo, J. Vidal H. Study of the regulation by nutrients of the expression of genes involved in lipogenesis and obesity in human and animal Nutr, Metab Cardiovasc. 11(4 Suppl):118-21 (2001)

Original Articles

  1. da Silva Xavier, G., Leclerc, I., Salt, I. Doiron, B., Hardie, D.G., Kahn, A., Rutter, G.A. Role of AMP-activated protein kinase in the regulation by glucose of islet b-cell gene expression Natl. Acad. Sci 97: 4023-4028 (2000)
  2. Rafiq I., Da Silva Xavier, G., Hooper, S., and G.A. Glucose-stimulated preproinsulin gene expression and nuclear translocation of pancreatic duodenum homeobox-1 (PDX-1), require activation of phosphatidyl inositol 3-kinase but not p38 MAPK/SAPK2, J. Biol. Chem. 275: 15977-15984 (2000)
  3. Ainscow, E.K., Zhao, C. and Rutter G.A. Acute over-expression of LDH-A perturbs glucose stimulated mitochondrial metabolism and insulin secretion Diabetes 49 (7), 1149 – 1155 (2000)
  4. Tsuboi, T., Zhao, C., Terakawa S. Rutter, G.A. Dynamics of insulin-containing vesicles: simultaneous evanescent wave imaging of the vesicle membrane and cargo during a single exocytotic event. Curr Biol. 10:1307-1310 (2000)
  5. da Silva Xavier, G., Varadi, A., Ainscow, E. K., Rutter, G. A. Regulation of gene expression by glucose in pancreatic b-cells (MIN6) via insulin secretion and activation of phosphatidyl inositol 3’ kinase Biol. Chem 275(46):36269-36277 (2000)
  6.  

Review Articles

  1. Rutter, G.A. and Tavaré, J.M. and Palmer, G., Regulation of gene expression by glucose. News in Physiological Sciences 15, 149-154 (2000)
  2. Rutter, G.A. And Rizzuto R., Local calcium signals tune mitochondrial activity in vivo. Trends Biochem. Sci. (2000) 25(5), 215-221
  3. G.A. Diabetes: the role of the liver. Curr. Biol. 10(20): R736-738 (2000)

Original Articles

  1. Midgley, P.J.W., Rutter, G.A., Thomas, A.P. & Denton, R.M. Effects of Ca2+and Mg2+on the activity of pyruvate dehydrogenase phosphate phosphatase within toluene-permeabilized mitochondria. J  241, 371-377 (1986)]
  2. Rutter, G.A. & Denton, R.M. Regulation of NAD+-linked isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase by Ca2+-ions within toluene-permeabilized rat heart mitochondria. J. 252, 181-189 (1988)
  3. Rutter, G.A. & Denton, R.M. Rapid purification of pig heart NAD+-isocitrate dehydrogenase. J. 263, 445-452 (1989)
  4. Rutter, G.A. & Denton, R.M. The binding of Ca2+-ions to pig heart NAD+-isocitrate dehydrogenase and the 2-oxoglutarate dehydrogenase complex. J. 263,.453-462 (1989)
  5. Rutter, G.A., Midgley, P.J.W. & Denton, R.M. Regulation of the pyruvate dehydrogenase complex by Ca2+within toluene-permeabilized heart mitochondria. Biochimica et Biophysica Acta 1014, 263 – 270 (1989)
  6. Rutter, G.A., Osbaldeston, N.J., McCormack, J.G. & Denton, R.M. Measurement of matrix Mg2+concentration of rat heart mitochondria using entrapped fluorescent probes. J. 271, 627 – 634 (1990)
  7. Rutter, G.A., Borthwick, A.C., & Denton, R.M. Effects of protein phosphatase inhibitors on the regulation of insulin-sensitive enzymes within rat epididymal fat pads and cells. Biochem J. 276, 649 – 654 (1991)
  8. Rutter, G.A. & Denton, R.M. Effects of insulin and guanosine-5’-[g-thio]diphosphate (GTP[S]) on fatty acid synthesis and lipolysis within electropermeabilized fat cells. Biochem J. 281, 431 – 435 (1992)
  9. Rutter, G.A., Diggle, T.A. & Denton, R.M. Regulation of pyruvate dehydrogenase by insulin and polyamines within electropermeabilized fat cells and isolated mitochondria. J. 285, 435 – 439 (1992)
  10. Rutter, G.A., Pralong, W-F., & Wollheim, C.B. Regulation of mitochondrial glycerol phosphate dehydrogenase activity by Ca2+within electropermeabilized insulin secreting cells (INS-1). Et Biophysica Acta, 1175, 107-113 (1992)
  11. Rutter, G.A. Theler, J-M., Murta, M., Wollheim, C.B., Pozzan, T. & Rizzuto, R. Stimulated Ca2+influx raises mitochondrial free Ca2+ to supramicromolar levels in a pancreatic ß-cell line: possible role in glucose and agonist-induced insulin secretion. Biol. Chem. 30, 22385-22390 (1993)
  12. Sekine, N., Cirulli,V., Regazzi, R., Brown, L.J., Gine, E., Tamarit-Rodriguez, J.,Girotti, M., Marie, S., MacDonald, M.J., Wollheim, C.B. & Rutter, G.A. Low lactate dehydrogenase and high mitochondrial glycerolphosphate dehydrogenase in pancreatic ß-cells: potential role in nutrient sensing. Biol. Chem. 269, 4895-4902 (1994)
  13. Rutter, G.A., Theler, J.-M., Li, G. and Wollheim, C.B. Ca2+stores in insulin secreting cells: Lack of effect of cyclicADP ribose. Cell Calcium 16, 71-80 (1994)
  14. Rutter, G.A., White, M.H., and Tavaré, J.M. Non-invasive imaging of gene expression in single living cells reveals MAP kinase involvement in insulin signalling. Current Biologie 5, 890-899 (1995)
  15. Rutter, G.A., Burnett, P. Rizzuto, R., Brini, M., Pozzan, T., Tavaré, J.M. and Denton, R.M. Digital imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity. Natl. Acad. Sci. 93, 5489-5494 (1996).  https://www.pnas.org/doi/abs/10.1073/pnas.93.11.5489 
  16. Birch, H.L., Rutter, G.A. and Goodship, A.E. Oxidative energy metabolism in equine tendon cells. Vet. Sci, 62, 93-97 (1997)
  17. Kennedy, H.J., Viollet, B., Rafiq, I., Kahn, A. and Rutter, G.A. Upstream stimulatory factor-2 (USF2) activity is required for glucose stimulation of L-pyruvate kinase promoter activity in single living islet b- cells. Biol. Chem. 272 20636 – 20640 (1997)
  18. Pouli, A.E., Karagenc, N., Arden, S. Bright, N., Schofield, G.S., Hutton, J.C. & Rutter, G.A. A phogrin-aequorin chimaera to image Ca2+ in the vicinity of secretory granules, J. 330, 1399 – 1404 (1998)
  19. Pouli, A.E., Kennedy, H.J., Schofield, G.S.& Rutter,G.A. Insulin targeting to the regulated secretory pathway after fusion with green fluorescent protein and firefly luciferase. J. 331, 669-675 (1998)
  20. Griffiths, E.J. Ocampo, C.J., Savage, J.S., Rutter, G.A.c, Stern, M.D. and Silverman, H. Mitochondrial calcium transporting pathways during hypoxia and reoxygenation in single rat cardiomyocytes Cardiovascular Res. 39, 423 – 433 (1998)
  21. Pouli, A.E., Emmanouilidou, E., Zhao, C., Wasmeier, C., Hutton J.C. Rutter, G.A. Secretory granule dynamics visualised in vivo with a phogrin.green fluorescent protein chimaera. J. 333 193-199 (1998)
  22. Zhao, C. and Rutter, G.A. Over expression of lactate dehydrogenase-A attenuates glucose-induced insulin secretion in stable MIN-6 b-cell lines, FEBS Lett 430, 213-216 (1998)
  23. Rafiq, I., Kennedy, H.J. and Rutter, G.A. Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 b-cells Biol. Chem. 273, 23 241- 23 247 (1998)
  24. Robb-Gaspers, L. Burnett, P. Rutter, G.A., Rizzuto, R. Denton, R.M., and Thomas, A.P. Regulation of mitochochondrial metabolism by Ca2+-dependent hormones J. 17, 4987 – 5000 (1998)
  25. Robb-Gaspers, L. Rutter, G.A., Burnett, P., Hajnozcy, G., Denton, R.M., and Thomas,A.P. Coupling between cytosolic and mitochondrial Ca2+ oscillations: Role in the regulation of hepatic metabolism. Biophys. Acta 1366, 17-32 (1998)
  26. Rutter, G.A., Kennedy, H.J., Wood, C, White, M.R.H, and Tavaré, J.M. Quantitative real-time imaging of gene expression in single cells using multiple luciferase reporters. Chemistry and Biologie 5, R285-R290 (1998)
  27. Kennedy, H.J., Pouli, A.E., Ainscow, E.K., Jouaville, L.S., Rizzuto, R. and Rutter, G.A. Glucose-induced ATP microdomains in single islet b-cells: role for strategically located mitochondria. Biol. Chem. 274 13 281-13 291 (1999)
  28. Kennedy, H.J., Rafiq, I., Pouli, A.E., Rutter, G.A. Glucose enhances insulin promoter activity in MIN6 b-cells independently of changes in intracellular Ca2+ concentration and insulin secretion. J. 342, 275-280 (1999)
  29. Emmanouilidou, E., Teschemacher, A., Pouli, A.E., Nicholls, L.I., Seward, E.P. and Rutter, G.A. Imaging [Ca2+] changes at the secretory vesicle surface with a recombinant targeted cameleon Biol 9, 915-918 (1999)
  30. Jouaville, L.S, Bastianutto, C., Pinton, P., Rutter, G.A. Rizzuto, R. Regulation of mitochondrial ATP synthesis by calcium: evidence for a long term, Ca2+-triggered, mitochondrial activation. Natl. Acad. Sci 96:13807-13812 (1999)
  31.  
  32.  

Review Articles

  1. Midgley, P.J.W., Rutter, G.A., Thomas, A.P. & Denton, R.M. The control of pyruvate dehydrogenase phosphate phosphatase. Soc. Trans. 15, 835-836 (1987)
  2. Rutter, G.A., Midgley, P.J.W. & Denton, R.M. Regulation of 2-oxoglutarate dehydrogenase and NAD+-linked isocitrate dehydrogenase within toluene-permeabilized mitochondria. Soc. Trans. 15, 834-835 (1988)
  3. Rutter, G.A. & Denton, R.M. Rapid purification and properties of pig heart NAD+-isocitrate dehydrogenase. Soc. Trans. 16, 873-874 (1988)
  4. Denton, R.M., McCormack, J.G., Midgley, P.J.W. & Rutter, G.A. Hormonal regulation of fluxes through pyruvate dehydrogenase and the Krebs citrate cycle in mammalian tissues. Soc. Symposium. 54, 127-143 (1987)
  5. Denton, R.M., McCormack, J.G., Midgley, P.J.W., Rutter, G.A. & Thomas, A.P. The role of Ca2+ in the hormonal control of intramitochondrial metabolism in heart, liver, and adipose tissue. Sec. Mess. And Phosphoprotein Res. 21, 157-164 (1988)
  6. Rutter, G.A. Ca2+-binding to citrate cycle enzymes. J. Biochem. 22, 1081 – 1088 (1990)
  7. Rutter, G.A., Osbaldeston, N.J., McCormack, J.G. & Denton, R.M. Measurement of matrix Mg2+ concentration of rat heart mitochondria using fluorescent probes. Soc. Trans. 18, 894 – 895 (1990)
  8. McCormack, J.G., Daniel, R.L., Osbaldeston, N.J., Rutter, G.A. & Denton, R.M. Mitochondrial Ca2+ transport and the rôle of matrix Ca2+ in mammalian tissues. Soc Trans. 20, 153 – 159 (1992)
  9. Denton, R.M., McCormack, J.G., Rutter, G.A., Burnett, P., Edgell, N.J., Moule, S.K. & Diggle, T.A. The hormonal regulation of the pyruvate dehydrogenase complex Enz. Reg. 36; 183-198(1996)
  10. Tavaré, J.M., Rutter, G.A., Griffiths, M.R., Dobson, S.P., Gray, H. The regulation of gene expression by insulin: analysis in single living cells Soc. Trans. 24, 378 – 384(1996)
  11. Rutter, G.A., Fasolato, C. and Rizzuto, R. Calcium and Organelles: a Two-sided Story Biochem. Res.Comm. 253: 549–557 (1998)
  12. Rutter, G.A.. Insulin secretion: Feed-forward control of insulin biosynthesis Biol. 9, R443-R445 (1999)
  13.  
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