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Recent Publications

Original Articles

Test. Zheng, X., Ho, Q.W.C., Chua, M., Steelmashenko, O., Muralidharan, S., Torta, F., Chew, E.G.Y., Lian, M.M., Foo, J.N., Rutter, G.A., Wenk, M., Silver, D.L., Berggren, O., and Ali, Y. Destabilization of β-cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes. Proc. Natl. Acad. Sci Mar 15;119(11):e2113074119. doi: 10.1073/pnas.2113074119. Epub 2022 Mar 7. (2022)

Zheng, X., Ho, Q.W.C., Chua, M., Steelmashenko, O., Muralidharan, S., Torta, F., Chew, E.G.Y., Lian, M.M., Foo, J.N., Rutter, G.A., Wenk, M., Silver, D.L., Berggren, O., and Ali, Y. Destabilization of β-cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes. Proc. Natl. Acad. Sci Mar 15;119(11):e2113074119. doi: 10.1073/pnas.2113074119. Epub 2022 Mar 7. (2022)

Pernaute, B., Perez-Montero, S, Sanchez-Nieto, J.M., di Gregorio, A., Lima, A., Lawlor, K., Bowling, S., Liccardi, G., Tomas, A., Meier, P., Sesaki, H., Rutter, G.A Barbaric, I., and Rodriguez, T.A. Drp1 regulation of mitophagy determines the apoptotic response upon embryonic differentiation. In press Dev Cell (2022)

Cao, H., Chung, A.C.K., Ming, X., Mao, D., Man Lee, H., Cao, X, Rutter, G.A., Chan, J.C.N., Tian, X.Y., and Kong, A.P.S. Autotaxin signaling facilitates β cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency. Mol Metab, in press (2022) 60:101493. doi: 10.1016/j.molmet.2022.101493. Online ahead of print.

Georgiadou, E., Muralidharan, C, Martinez, M., Chabosseau, P., Tomas, A., Yong Su Wern, G., Stylianides, T., Wretland, A., Leguido-Quigley, C., Alsabeeh, N., Cruciani-Guglielmacci, C., Magnan, C., Ibberson, M., Leclerc, I., Ali, Y., Linnemann, A.K. Rodriguez, T.A., and Rutter, G.A. Mitofusins Mfn1 and Mfn2 are required in the β-cell to preserve glucose but not incretin induced beta cell connectivity and insulin secretion,. Diabetes in press (2022) doi: 10.2337/db21-0800. Online ahead of print.

Cheung, R., Pizza, G., Chabosseau, P., Rolando, D., Tomas, A., Burgoyne, T., Wu, Z., Salowska, A., Tapa, A.,Macklin, A., Cao, Y., Nguyen-Tu, M.S., Dickerson, M.T., Jacobson, D.A., Marchetti, P., Shapiro, J., Piemonti, L., de Koning,E., Leclerc, I., Bouzakri, K., Sakamoto, K., Smith, D.M., Rutter, G.A. and Martinez-Sanchez, A. Glucose-dependent mir-125b is a negative regulator of β cell function. Diabetes in press (2022) doi: 10.2337/db21-0803. Online ahead of Akalestou, E., Lopez-Noriega, Iain Tough, Ming Hu, Leclerc, I., Helen C. Cox., and Rutter G.A. Vertical Sleeve Gastrectomy lowers SGLT2 expression in the mouse kidney. Diabetes, May 20:db210768. doi: 10.2337/db21-0768. Online ahead of print. (2022)

Akalestou, E., Lopez-Noriega, Iain Tough, Ming Hu, Leclerc, I., Helen C. Cox., and Rutter G.A. Vertical Sleeve Gastrectomy lowers SGLT2 expression in the mouse kidney. Diabetes, May 20:db210768. doi: 10.2337/db21-0768. Online ahead of print. (2022)

Cruciani-Guglielmacci, C., Meneyrol, K., Denom, J., Kassis, N., Rachdi, L., Makaci, F., Migrenne-Li, S., Daubigney, F., Georgiadou, E., Denis, R.G., Rodriguez Sanchez-Archidona, A., Paul, J-L., Thorens, B., Rutter, G.A, Magnan, C., Le Stunff, H., Janel, N. Homocysteine metabolism pathway is involved in the control of glucose homeostasis: a cystathionine beta synthase deficiency study in Mouse, in press Cells May 25;11(11):1737. doi: 10.3390/cells11111737 (2022)

Jones, B., Burade, V., Akalestou, E., Manchanda, Y., Ramchunder, Z., Carrat, G., Nguyen-Tu, M.-S., Marchetti, P., Piemonti, P., Leclerc, I., Thennati, R., Visboll, T., Thorens, B., Tomas, A and Rutter G.A. In vivo and in vitro characterisation of GL0034, a novel long-acting GLP-1 receptor agonist. In press Diabetes Obesity and Metabolism, 24(11):2090-2101. doi: 10.1111/dom.14794. (2022)

Bosi, I., Marchetti, P., Rutter, G.A., Eizirik, D.L. Gene signatures of human alpha cells in types 1 and 2 diabetes indicate disease-specific pathways of alpha cell dysfunction. iScience, 25(10):105056. doi: 10.1016/j.isci.2022.105056 (2022)

Review Articles

Benninger, R., Dorreell, C., Hodson, D.J., Rutter, G.A. The impact of pancreatic β cell heterogeneity on the pathogenesis of type 1 diabetes. Curr Diab Rep 18(11):112 (2018)

Da Silva Xavier, G., and Rutter, G.A. Metabolic and functional heterogeneity in pancreatic β cells. For J Mol. Biol, special edition “Islet biology in type 2 diabetes” Eds, Gaisano, H., Jonas, J.C., and Gloyn, A. (2019b uenaventura) Aug 13. pii: S0022-2836(19)30508-X. doi: 10.1016/j.jmb.2019.08.005. (2019)

Marchetti, P., Schulte, A., Marselli, L., Schonger, E., Bugliani, M., Kramer, W., Overburgh, L., Ullrich, S., Gloyn, A., Ibberson, M., Rutter, G., Froguel, P., Groop, L., McCarthy, M., Eizirik, D.L., Mathieu, C., Cnop, M., Thorens, B., Solimena, M. Fostering improved human islet research – A European Perspective. Diabetologia, 62(8):1514-1516 (2019)

Rutter G.A. Pancreatic Islet Secretion: Gabbling via GABA. News and Views article for Nature Metabolism. 1(11):1032-1033 (2019)

Khan, R., Tomas, A. and Rutter, G.A. Effects on Pancreatic Beta and other Islet Cells of the Glucose-dependent Insulinotropic Polypeptide. Peptides, 125:170201 (2020)

Georgiadou, E. and Rutter, G.A. Highlight: Yau et al A fluorescent timer reporter enables sorting of insulin secretory granules by age. J. Biol. Chem 295(27):8912-8913. doi: 10.1074/jbc.H120.014586 (2020)

Rutter, G.A., Ninov, N, Salem, V., Hodson, D.J. Comment on “Take me to your leader: an electrophysiological appraisal of the role of hub cells in pancreatic islets” by Satin et al. Diabetes, Sep;69(9):e10-e11. doi: 10.2337/db20-050110/5/2020 (2020)

Rutter,  G.A., McCormack, J.G., Halestrap, A.P. and Denton, R.M. The roles of cytosolic and intramitochondrial Ca2+ and the mitochondrial Ca2+-uniporter (MCU) in the stimulation of mammalian oxidative phosphorylation eLetter, J. Biol Chem, Jul 24;295(30):10506. doi: 10.1074/jbc.L120.013975 (2020)

Georgiadou, E., and Rutter, G.A. Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells. Cell Calcium. 91:102282. doi: 10.1016/j.ceca.2020.102282 (2020)

Muniangi-Muhitu, H., Akalestou, E., Salem, V., Misra, S., Oliver, N.S., Rutter, G.A. Covid-19 and diabetes: a complex bidirectional relationship. Front. Endo. https://doi.org/10.3389/fendo.2020.582936 (2020)

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2024
  1. Carapeto, P., Jiho Kahng, J., Alves-Wagner, A.B., Middelbeek, R.J.W., Hirshman, M.F., Rutter, G.A. Goodyear, L.J., and Aguayo-Mazzucato, C. Exercise activates AMPK in mouse and human pancreatic islet leading to decreased senescence. Nature Metabolism, in press (2024)
  2. Haberman, N., Cheung, R., Pizza, G., Cvetesic, N., Nagy, D., Maude, H., Blazqueez, L., Lenhard, B., Cebola, I., Rutter, G.A.* and Martinez-Sanchez, A. Liver kinase B1 (LKB1) regulates the epigenetic landscape of mouse pancreatic beta cells. FASEB J 38(16):e23885. doi: 10.1096/fj.202401078R (2024) *co-corresponding author
  3. Manchanda, Y., ElEid, L., Oqua, A.I., Ramchunder, Z., Choi, J., Shchepinova, M.M., Rutter, G.A., Asuka Inoue, A., Tate, E.W., Jones, B.,  and Tomas, A. Engineered mini-G proteins block the internalization of cognate GPCRs and disrupt downstream intracellular signaling. In press Science Signalling, 2024
  4. Delgadillo Silva, L.F., Singh, S.P., Georgiadou, E., Rutter, G.A.* and Ninov, N. Optical interrogation of β-cell activity in situ identifies two highly functional subpopulations of pancreatic β-cells” in press Sci Adv (2024) *Co-corresponding author
  5. Suba, K., Patel, Y., Roberts, A. Martin Alonso, A., Roberts, A., Hansen, B., Norton, M., Shrewsbury, J.V., Chen, S, Kwok, R., Kalogianni, V., Chen, S., Liu, X., Rutter, G.A., Jones, B., Minnion, J., Owen, B., Distaso, W., Drucker, D.J., Tan, M., Bloom, S.J., Murphy, K., Salem, V. Intra-islet glucagon regulates pulsatile insulin secretion and glucose homeostasis. Molecular Metabolism in press  10.1016/j.molmet.2024.101947 (2024)
  6. Cuozzo, F., Viloria, K., Shileh, A.H., Nasteka, D., Frazer-Morris, C., Tong, J., Jiao, Z., Boufersaoui, A., Marzullo, B., Rosoff, D.B., Smith, H.R., Bonner, C., Kerr-Conte, J., Pattou, F., Nano, R., Piemonti, L., Johnson, P.R.V., Speirs, R., Roberts, J., Lavery, G.G., Clark, A., Ceresa, C.D.L., Ray, D.W., Hodson, L., Davies, A., Rutter, G.A., Shima, M., Scharfmann, R., Merrins, J., Akermann, I., Tennant, D., Ludwig, C. and Hodson, D.J. LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells. Cell Reports  Apr 23;43(4):114047. doi: 10.1016/j.celrep.2024.114047. Epub 2024 Apr 11 (2024)
  7. Hu, M., Kim, I., Moran, I., Peng, W., Sun, O., Bonnefond, A., Bonas-Guarch, S., Froguel, P., Rutter, G.A. Multiple Genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β cell survival and function FASEB J 38(8):e23610. doi: 10.1096/fj.202301700RR (2024).
  8. Ghiasi, S.M., Marchetti, P., Piemonti, L., Nielson, J.N., Porse, B.Y., mandrup-Poulse, T., and Rutter, G.A. Proinflammatory Cytokines, but not Glucolipotoxicity, Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells. Front. Endo., Mar 22;15:1359147. doi: 10.3389/fendo.2024.1359147 (2024)
  9. Li, S., Dragan,, I, Tran, V.D.T., Fung, C.H., Kuznetsov, D., Hansen, M.K., Beulens, J.W.J., ’t Hart, L.M., Slieker, R.C., Donnelly, L.A., Gerl, M.J., Klose, C., Mehl, F., Simons, K., Elders, P.J.M., Pearson, E.P., Rutter, G.A*. and Ibberson, M.* Multi-omics clusters associated with progression in type 2 diabetes: an IMI-RHAPSODY Study. Front. Endo, 15:1350796. doi: 10.3389/fendo.2024.1350796. 22 nd Feb, (2024)   * co-corresponding author
  10. Yu, V., Yong, F., Marta, A., Khadayate, S., Osakwee, A., Bhattacharya, S.S., Varghese, S.S., Chabosseau, P., Tabibi, S.M., Chen, K., Georgiadou, E., Parveen, N., Suleiman, M., Stamoulis, Z., Marselli, L., de Luca C., Tesi, M., Ostinelli, G., Delgadillo Silva, L., Wu, X., Hatanaka, Y., Montoya, A., Elliot, J., Patel, B., Demchenko, N., Wilding C., Hajkova, P., Schliaha, P., Kramer, H., Ali, Y., Marchetti, P., Sladek, R., Dhawan, S., Withers, D.J., Rutter, G.A.* and Millership, S.J. Establishment of beta cell heterogeneity via differential CpG methylation at Nnat. In press Diabetologia (2024). * co-corresponding author
  11. Slieker, R.C., Munch, M., Donnelly, L.A., Bouland, G., Dragon, I., Kuznetsov, D, Elders, P., Rutter, G.A., Ibberson, M., Pearson, E.R., ‘t Hart, L.M., van de Wiel, M.A., and Beulens, J.W.L. A multi-omics machine learning approach to predict diabetes progression: a RHAPSODY study. In press at Diabetologia (2024)
  1. So, W.Y., Liao, Y, Nam Liu, W, Rutter, G.A., Han, W. Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy. EMBO Mol Med, e17928. doi: 10.15252/emmm.202317928 (2023)
  2. Firth, G., Georgiadou, E, Griffiths, A., Amrahli, M., Kim, J., Yu, Z., Hu, M., Stewart, T.J., Leclerc, I., Okamoto, H., Gomez, D., Blower, P.J. and Rutter, G.A. Impact of an SLC30A8 loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice. Fronters Endocrinology, Diabetes: Molecular Metabolism, 14:1171933. doi: 10.3389/fendo.2023.1171933. eCollection (2023)
  3. Xiao J, El Eid L, Buenaventura T, Boutry R, Bonnefond A, Jones B, Rutter GA, Froguel P, Tomas A. Control of human pancreatic beta cell kinome by glucagon-like peptide-1 receptor biased agonism. Diabetes Obes Metab. 2023 Aug;25(8):2105-2119. doi: 10.1111/dom.15083. Epub 2023 Apr 25. PMID: 37039251.
  4. Bitsi, S., Manchanda, Y., El Eid, L., Mohamed, N., Hansen, B., Suba, K., Rutter, G.A., Salem, V., Jones, B., Tomas, A. Divergent acute versus prolonged in vivo GLP-1R responses in β-arrestin 2-deleted primary beta cells. In press Science Advances (2023)
  1. Carapeto, P., Jiho Kahng, J., Alves-Wagner, A.B., Middelbeek, R.J.W., Hirshman, M.F., Rutter, G.A. Goodyear, L.J., and Aguayo-Mazzucato, C. Exercise activates AMPK in mouse and human pancreatic islet leading to decreased senescence. Nature Metabolism, in press (2024)
  2. Haberman, N., Cheung, R., Pizza, G., Cvetesic, N., Nagy, D., Maude, H., Blazqueez, L., Lenhard, B., Cebola, I., Rutter, G.A.* and Martinez-Sanchez, A. Liver kinase B1 (LKB1) regulates the epigenetic landscape of mouse pancreatic beta cells. FASEB J 38(16):e23885. doi: 10.1096/fj.202401078R (2024) *co-corresponding author
  3. Manchanda, Y., ElEid, L., Oqua, A.I., Ramchunder, Z., Choi, J., Shchepinova, M.M., Rutter, G.A., Asuka Inoue, A., Tate, E.W., Jones, B.,  and Tomas, A. Engineered mini-G proteins block the internalization of cognate GPCRs and disrupt downstream intracellular signaling. In press Science Signalling, 2024
  4. Delgadillo Silva, L.F., Singh, S.P., Georgiadou, E., Rutter, G.A.* and Ninov, N. Optical interrogation of β-cell activity in situ identifies two highly functional subpopulations of pancreatic β-cells” in press Sci Adv (2024) *Co-corresponding author
  5. Suba, K., Patel, Y., Roberts, A. Martin Alonso, A., Roberts, A., Hansen, B., Norton, M., Shrewsbury, J.V., Chen, S, Kwok, R., Kalogianni, V., Chen, S., Liu, X., Rutter, G.A., Jones, B., Minnion, J., Owen, B., Distaso, W., Drucker, D.J., Tan, M., Bloom, S.J., Murphy, K., Salem, V. Intra-islet glucagon regulates pulsatile insulin secretion and glucose homeostasis. Molecular Metabolism in press  10.1016/j.molmet.2024.101947 (2024)
  6. Cuozzo, F., Viloria, K., Shileh, A.H., Nasteka, D., Frazer-Morris, C., Tong, J., Jiao, Z., Boufersaoui, A., Marzullo, B., Rosoff, D.B., Smith, H.R., Bonner, C., Kerr-Conte, J., Pattou, F., Nano, R., Piemonti, L., Johnson, P.R.V., Speirs, R., Roberts, J., Lavery, G.G., Clark, A., Ceresa, C.D.L., Ray, D.W., Hodson, L., Davies, A., Rutter, G.A., Shima, M., Scharfmann, R., Merrins, J., Akermann, I., Tennant, D., Ludwig, C. and Hodson, D.J. LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells. Cell Reports  Apr 23;43(4):114047. doi: 10.1016/j.celrep.2024.114047. Epub 2024 Apr 11 (2024)
  7. Hu, M., Kim, I., Moran, I., Peng, W., Sun, O., Bonnefond, A., Bonas-Guarch, S., Froguel, P., Rutter, G.A. Multiple Genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β cell survival and function FASEB J 38(8):e23610. doi: 10.1096/fj.202301700RR (2024).
  8. Ghiasi, S.M., Marchetti, P., Piemonti, L., Nielson, J.N., Porse, B.Y., mandrup-Poulse, T., and Rutter, G.A. Proinflammatory Cytokines, but not Glucolipotoxicity, Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells. Front. Endo., Mar 22;15:1359147. doi: 10.3389/fendo.2024.1359147 (2024)
  9. Li, S., Dragan,, I, Tran, V.D.T., Fung, C.H., Kuznetsov, D., Hansen, M.K., Beulens, J.W.J., ’t Hart, L.M., Slieker, R.C., Donnelly, L.A., Gerl, M.J., Klose, C., Mehl, F., Simons, K., Elders, P.J.M., Pearson, E.P., Rutter, G.A*. and Ibberson, M.* Multi-omics clusters associated with progression in type 2 diabetes: an IMI-RHAPSODY Study. Front. Endo, 15:1350796. doi: 10.3389/fendo.2024.1350796. 22 nd Feb, (2024)   * co-corresponding author
  10. Yu, V., Yong, F., Marta, A., Khadayate, S., Osakwee, A., Bhattacharya, S.S., Varghese, S.S., Chabosseau, P., Tabibi, S.M., Chen, K., Georgiadou, E., Parveen, N., Suleiman, M., Stamoulis, Z., Marselli, L., de Luca C., Tesi, M., Ostinelli, G., Delgadillo Silva, L., Wu, X., Hatanaka, Y., Montoya, A., Elliot, J., Patel, B., Demchenko, N., Wilding C., Hajkova, P., Schliaha, P., Kramer, H., Ali, Y., Marchetti, P., Sladek, R., Dhawan, S., Withers, D.J., Rutter, G.A.* and Millership, S.J. Establishment of beta cell heterogeneity via differential CpG methylation at Nnat. In press Diabetologia (2024). * co-corresponding author
  11. Slieker, R.C., Munch, M., Donnelly, L.A., Bouland, G., Dragon, I., Kuznetsov, D, Elders, P., Rutter, G.A., Ibberson, M., Pearson, E.R., ‘t Hart, L.M., van de Wiel, M.A., and Beulens, J.W.L. A multi-omics machine learning approach to predict diabetes progression: a RHAPSODY study. In press at Diabetologia (2024)
  1. Carapeto, P., Jiho Kahng, J., Alves-Wagner, A.B., Middelbeek, R.J.W., Hirshman, M.F., Rutter, G.A. Goodyear, L.J., and Aguayo-Mazzucato, C. Exercise activates AMPK in mouse and human pancreatic islet leading to decreased senescence. Nature Metabolism, in press (2024)
  2. Haberman, N., Cheung, R., Pizza, G., Cvetesic, N., Nagy, D., Maude, H., Blazqueez, L., Lenhard, B., Cebola, I., Rutter, G.A.* and Martinez-Sanchez, A. Liver kinase B1 (LKB1) regulates the epigenetic landscape of mouse pancreatic beta cells. FASEB J 38(16):e23885. doi: 10.1096/fj.202401078R (2024) *co-corresponding author
  3. Manchanda, Y., ElEid, L., Oqua, A.I., Ramchunder, Z., Choi, J., Shchepinova, M.M., Rutter, G.A., Asuka Inoue, A., Tate, E.W., Jones, B.,  and Tomas, A. Engineered mini-G proteins block the internalization of cognate GPCRs and disrupt downstream intracellular signaling. In press Science Signalling, 2024
  4. Delgadillo Silva, L.F., Singh, S.P., Georgiadou, E., Rutter, G.A.* and Ninov, N. Optical interrogation of β-cell activity in situ identifies two highly functional subpopulations of pancreatic β-cells” in press Sci Adv (2024) *Co-corresponding author
  5. Suba, K., Patel, Y., Roberts, A. Martin Alonso, A., Roberts, A., Hansen, B., Norton, M., Shrewsbury, J.V., Chen, S, Kwok, R., Kalogianni, V., Chen, S., Liu, X., Rutter, G.A., Jones, B., Minnion, J., Owen, B., Distaso, W., Drucker, D.J., Tan, M., Bloom, S.J., Murphy, K., Salem, V. Intra-islet glucagon regulates pulsatile insulin secretion and glucose homeostasis. Molecular Metabolism in press  10.1016/j.molmet.2024.101947 (2024)
  6. Cuozzo, F., Viloria, K., Shileh, A.H., Nasteka, D., Frazer-Morris, C., Tong, J., Jiao, Z., Boufersaoui, A., Marzullo, B., Rosoff, D.B., Smith, H.R., Bonner, C., Kerr-Conte, J., Pattou, F., Nano, R., Piemonti, L., Johnson, P.R.V., Speirs, R., Roberts, J., Lavery, G.G., Clark, A., Ceresa, C.D.L., Ray, D.W., Hodson, L., Davies, A., Rutter, G.A., Shima, M., Scharfmann, R., Merrins, J., Akermann, I., Tennant, D., Ludwig, C. and Hodson, D.J. LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells. Cell Reports  Apr 23;43(4):114047. doi: 10.1016/j.celrep.2024.114047. Epub 2024 Apr 11 (2024)
  7. Hu, M., Kim, I., Moran, I., Peng, W., Sun, O., Bonnefond, A., Bonas-Guarch, S., Froguel, P., Rutter, G.A. Multiple Genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β cell survival and function FASEB J 38(8):e23610. doi: 10.1096/fj.202301700RR (2024).
  8. Ghiasi, S.M., Marchetti, P., Piemonti, L., Nielson, J.N., Porse, B.Y., mandrup-Poulse, T., and Rutter, G.A. Proinflammatory Cytokines, but not Glucolipotoxicity, Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells. Front. Endo., Mar 22;15:1359147. doi: 10.3389/fendo.2024.1359147 (2024)
  9. Li, S., Dragan,, I, Tran, V.D.T., Fung, C.H., Kuznetsov, D., Hansen, M.K., Beulens, J.W.J., ’t Hart, L.M., Slieker, R.C., Donnelly, L.A., Gerl, M.J., Klose, C., Mehl, F., Simons, K., Elders, P.J.M., Pearson, E.P., Rutter, G.A*. and Ibberson, M.* Multi-omics clusters associated with progression in type 2 diabetes: an IMI-RHAPSODY Study. Front. Endo, 15:1350796. doi: 10.3389/fendo.2024.1350796. 22 nd Feb, (2024)   * co-corresponding author
  10. Yu, V., Yong, F., Marta, A., Khadayate, S., Osakwee, A., Bhattacharya, S.S., Varghese, S.S., Chabosseau, P., Tabibi, S.M., Chen, K., Georgiadou, E., Parveen, N., Suleiman, M., Stamoulis, Z., Marselli, L., de Luca C., Tesi, M., Ostinelli, G., Delgadillo Silva, L., Wu, X., Hatanaka, Y., Montoya, A., Elliot, J., Patel, B., Demchenko, N., Wilding C., Hajkova, P., Schliaha, P., Kramer, H., Ali, Y., Marchetti, P., Sladek, R., Dhawan, S., Withers, D.J., Rutter, G.A.* and Millership, S.J. Establishment of beta cell heterogeneity via differential CpG methylation at Nnat. In press Diabetologia (2024). * co-corresponding author
  11. Slieker, R.C., Munch, M., Donnelly, L.A., Bouland, G., Dragon, I., Kuznetsov, D, Elders, P., Rutter, G.A., Ibberson, M., Pearson, E.R., ‘t Hart, L.M., van de Wiel, M.A., and Beulens, J.W.L. A multi-omics machine learning approach to predict diabetes progression: a RHAPSODY study. In press at Diabetologia (2024)
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The mission of our laboratory is to use functional genomics at the cellular and whole organism level to find new ways to enhance insulin secretion in diabetes mellitus.

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